Changliang Ren, Ph.D.
Professor
Experience
2020 - now: Professor, School of Pharmaceutical Sciences, Xiamen University
2019-2020: Research Scientist, NanoBio Lab, A*STAR, Singapore
2014-2019: Research Scientist, Institute of Bioengineering and Nanotechnology, A*STAR, Singapore
2012-2014: Scientist I, Institute of Materials Research and Engineering, A*STAR, Singapore
2011-2012: Research Assistant, Department of Chemistry, National University of Singapore
Education
2007 – 2012: Ph. D., National University of Singapore, Singapore
2003 – 2007: B. Sc., Sichuan University, China
Research
Artificial ion channels: Ion channels play an important role in maintaining the electrolyte balance between the intra- and extracellular medium and have been involved in a lot of biologically important processes. Mis-regulations of ion transport are closely associated with a lot of life-threatening diseases. Our group is working on the synthesis of small molecules that would form ion channels in the membrane to efficiently and highly selectively transport specific ions. These synthetic molecules have shown promising application as anticancer or anti-hepatic fibrosis agents.
Selected Publications:
1、Q. Zhang, Q. Liang, G. Wang, X. Xie, Y. Cao, N. Sheng, Z. Zeng and C. Ren*, “Highly Selective Artificial K+ Transporters Reverse Liver Fibrosis In Vivo” JACS Au 2024, DOI: 10.1021/jacsau.4c00521.
2. J. Shen, Y. Gu, L. Ke, Q. Zhang, Y. Cao, Y. Lin, Z. Wu, C. Wu, Y. Mu, Y.-L. Wu, C. Ren*, H. Zeng*, Cholesterol-stabilized membrane-active nanopores with anticancer activities. Nat. Commun. 2022, 13, 5985.
3. C. Ren, F. Chen, R. Ye, Y. S. Ong, H. Lu, S. S. Lee, J. Y. Ying and H. Zeng*, “Molecular Swings as Highly Active Ion Transporters,” Angew. Chem. Int. Ed. 2019, 58, 8034-8038 (Hot Paper, News Reports in Asia Today, Asia Pacific Biotech News)
4. R. Ye#, C. Ren#, J. Shen, N. Li, F. Chen, A. Roy and H. Zeng*, “Molecular Ion Fishers as Highly Active and Exceptionally Selective K+ Transporters,” J. Am. Chem. Soc. 2019, 141, 9788-9792. (# equal contribution)
5. C. Ren, F. Zeng, J. Shen, F. Chen, A. Roy, S Zhou, H. Ren and H. Zeng*, “Pore-forming Monopeptides as Exceptionally Active Anion Channels,” J. Am. Chem. Soc. 2018, 140, 8817-8826. (Featured in Asian Scientist)
6. C. Ren, J. Shen and H. Zeng*, “Combinatorial Evolution of Fast-Conducting Highly Selective K+-Channels via Modularly Tunable Directional Asembly of Crown Ethers,” J. Am. Chem. Soc. 2017, 139, 12338-12341. (Featured in Phys.org)
7. C. Ren, J. Shen, F. Chen and H. Zeng*, “Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator,” Angew. Chem. Int. Ed. 2017, 56, 3847-3851
8. C. Ren, X. Ding, A. Roy, J. Shen, S Zhou, F. Chen, S. F. Y. Li, H. Ren, Y. Y. Yang and H. Zeng*, “A Halogen-bond Mediated Highly Active Artificial Chloride Channel with High Anti-cancer Activity,” Chem. Sci. 2018, 9, 4044-4051. (Outside Cover, Featured in Chemistry Views)
Tel: +86-592-2182453
Email: changliang.ren@xmu.edu.cn
