Zhixiang Lu, Ph.D.
Associate Professor
Experience
04/2023-Present, Xiamen University, Associate Professor
03/2020-03/2023, Xiamen University, Biochemistry,Postdoctoral Fellow
Education
09/2017 – 12/2019, Yunnan University, Organic Chemistry,Ph.D.
09/2010 – 06/2014, Yunnan University, Pharmaceutical Engineering, B.Eng.
Research
Focusing on novel functional drug design, microenvironment responsive probes and delivery carriers, the main areas of my research include:
Designing multifunctional novel organometallic active drugs and revealing their anti-tumor molecular mechanisms;
Constructing targeted and intelligent specific imaging probes to provide effective pathways for disease diagnosis;
Studying microenvironment-responsive drugs and gene delivery carriers to improve drug targeting and safety, enhance drug efficacy, control drug release time, reduce dosage, etc.
Selected Publications:
1. Dazhuang Xu, Jianlin Ge, Yibo An, Shuang Bai, Ziying Wang, Shuaiying Wu, Qixuan Dai, Zhixiang Lu*, and Gang Liu*, Molecular Engineering of NIR-II/IIb Emitting AIEgen for Multimodal Imaging-Guided Photo-Immunotherapy, Small, 2023, 23008.
2. Shuaiying Wu a, #, Jianzhong Zhang a, #, Jie pan a, Shuang Bai a, Ziying Wang b, Yulun Chen c, Dazhuang Xu a, Yibo An a, Chao Liu a, Chengchao Chu c, Qixuan Dai a, Zhixiang Lua, *, Gang Liu a, b, *, Integrated nanorods-mediated PD-L1 downregulation in combination with oxidative-stress immunogene therapy against cancer. Advanced Healthcare Materials, 2023: 2300110.
3. Shuaiying Wu a, Chao Liu a, Shuang Bai a, Zhixiang Lua, *, Gang Liu a, b, *, Broadening the horizons of RNA delivery strategies in cancer therapy. Bioengineering, 2022, 9, 576.
4. Zhixiang Lua, #, Shuang Bai a, #, Yonghe Jiang b, Shuaiying Wu a, Dazhuang Xu a, Jianzhong Zhang a, Xuqi Peng a, Hongrui Zhang a, Yesi Shi a, *, Gang Liu a, b, *，Amplifying Dendritic Cell Activation by Bioinspired Nanometal Organic Frameworks for Synergistic Sonoimmunotherapy, Small, 2022, 2203952.
5. Zhixiang Lu#, Shuang Bai #, Yonghe Jiang, Shuaiying Wu, Dazhuang Xu ,Yulun Chen, Yulu Lan，Yibo An, Jingsong Mao, Xuan Liu *, Gang Liu *, Porphyrin-based Covalent organic framework for imaging-guided combinatorial immune-sonodynamic therapy. Advanced Functional Materials, 2022, 2207749.
6. Shuang Bai #, Yulu Lan #, Shiying Fu, Jintao Pan, Zhixiang Lu *, Gang Liu *，Connecting Calcium-Based Nanomaterials and Cancer: from Diagnosis to Therapy. Nano-micro letter, 2022, 14(1),145.
7. Shuang Bai #, Zhixiang Lu#, Yonghe Jiang, Xiaoxiao Shi, Yesi Shi, Gan Lin, Chao Liu, Yang Zhang*, Gang Liu*, Nanotransferrin-based programmable catalysis mediates triple oxidative stress to boost immunogenic cell death for anti-tumor immunity. ACS nano, 2022, 16, 1, 997–1012.
8. Zhixiang Lu#, Shuang Bai #, Yesi Shi, Dazhuang Xu, Chengchao Chu *, Gang Liu *, Artificial nanocages-based 3D framework platforms: from construction design to biological applications. Chemical Engineering Journal, 2021, 426, 131891.
9. Zhixiang Lu, Mingjiang Wu, Shuang Wu, Shaoxiong Yang, Yuan Li, Xiaolan Liu, Liyan Zheng *, Qiue Cao * and Zhongtao Ding, Modulating the optical properties of the AIE fluophor confined within UiO-66's nanochannels for chemical sensing. Nanoscale, 2016, 8(40): 17489-17495.
10. Zhixiang Lu, Shaoxiong Yang, Xiaolan Liu, Yu Qin, Shuhan Lu, Yanxiong Liu, Ruidun Zhao, Liyan Zheng*, Hongbin Zhang *, Facile synthesis and separation of E /Z isomers of aromatic-substituted tetraphenylethylene for investigating their fluorescent properties via single crystal analysis. Journal of Materials Chemistry C, 2019, 7(14): 4155-4163.
11. Zhixiang Lu, Yanxiong Liu, Xiaolan Liu, Shuhan Lu, Yuan Li, Shaoxiong Yang, Yu Qin, Liyan Zheng *, Hongbin Zhang *, A hollow microshuttle-shaped capsule covalent organic framework for protein adsorption, Journal of Materials Chemistry B, 2019, 7(9): 1469-1474.
12. Zhixiang Lu, Yi Cheng, Wenwen Fan, Shaoxiong Yang, Xiaolan Liu, Yu Qin, Ruidun Zhao, Liyan Zheng * and Hongbin Zhang *, A stable silver metallacage with solvatochromic and mechanochromic behaviors for white LED fabrication. Chemical Communications, 2019, 55, 8474-8477.
13. Zhixiang Lu, Shuhan Lu, Yi Cheng, Yu Qin, Shaoxiong Yang, Xiaolan Liu, Wenwen Fan, Liyan Zheng *, Hongbin Zhang *, Synthesis of isoniazid-substituted tetraphenylethylene stereoisomers with dramatic differences on aggregate morphologies, optical and mechanocharomic properties. Journal of Photochemistry & Photobiology A: Chemistry, 2020, 392: 112357-112368.
14. Zhixiang Lu, Yunming Liu, Shuhan Lu, Yuan Li, Xiaolan Liu, Yu Qin and Liyan Zheng *, A highly selective TPE-based AIE fluorescent probe is developed for the detection of Ag+. RSC advances, 2018, 8(35): 19701-19706.
15. Yonggang Shi#, Zhixiang Lu#, Liyan Zheng *, Qiu-E Cao *，Silver-Driven Coordination Self-Assembly of Tetraphenylethene Stereoisomer: Construct Charming Topologies and Their Mechanochromic Behaviors. Inorganic Chemistry,2020, 59, 6508-6517.
16. Yonghe Jiang #, Yang Zhang #, Zhixiang Lu#, Xiaoyong Wang, Shuang Bai, Yulun Chen, Jinsong Mao *, Gang Liu *, Liquid Embolic Agents for Interventional Embolization. ChemPhysMater,2022, 1, 39–50.
17. 吴帅莹，蒋永和，陆治香*，刘刚*, 液体硅橡胶功能改性及其医学应用研究进展。中国材料进展。接收。
18. 许大壮, 潘金韬, 陆治香*, 刘刚*，近红外二区有机荧光纳米探针构建及手术导航研究进展。生命科学仪器，2021,19 (01), 4-11。
Tel: +86-15287100769
Email: zhixiangl@xmu.edu.cn
