Qing Chen, Ph.D.
Associate Professor
Experience
2020-now Associate Professor, School of Pharmaceutical Sciences, Xiamen University
2010-2020 Assistant Professor, School of Pharmaceutical Sciences, Xiamen University
2005-2010 PhD, Traditional Chinese Medicine, School of Traditional Chinese Pharmacy, China Pharmaceutical University
2001-2005 Bachelor, Pharmacy, Fujian Medical University
Research
We have been committed to quality control of drugs and the research and development of effective components of Traditional Chinese Medicine. With molecular imprinting and electrochemical technology as the core, we have conducted accurate and efficient rapid detection of genes, proteins and other biological targets in complex substrates (such as blood samples and extracts of Traditional Chinese Medicine), and optimized the process of separation and analysis of effective components with low content. The method is advanced and the results have been published in high-level papers.
Main research directions:
1. Molecular imprinting technology in pharmaceutical analysis.
2. Application of electrochemistry in the analysis of active components or targets in complex matrix.
3. Product development and quality evaluation of active ingredients of Traditional Chinese Medicine.
Selected Publications (last 5 years):
(1) Jingbo Zhang(†), Quancheng Chen(†), Xuemin Gao, Qian Lin, Ziqin Suo, Di Wu, Xijie Wu*, Qing Chen*.A Label-free and Antibody-free Molecularly Imprinted Polymer-based Impedimetric Sensor for NSCLC cells Derived Exosomes Detection. Biosensors, 2023, 13(6), 647 https://doi.org/10.3390/bios13060647
(2) Huayu Yang (†), Hua Song (†), Ziqin Suo, Funan Li, Quanyi Jin, Xuan Zhu*, Qing Chen * A molecularly imprinted electrochemical sensor based on surface imprinted polymerization and boric acid affinity for selective and sensitive detection of P-glycoproteins.Analytica Chimica Acta, 2022, 1207: 339797
(3) Qing Chen (†) *, Xinmei Liu (†), Huayu Yang, Shuyi Zhang, Hua Song, Xuan Zhu *. Preparation and evaluation of magnetic graphene oxide molecularly imprinted polymers (MIPs-GO-Fe3O4@SiO2) for the analysis and separation of tripterine. Reactive and Functional Polymers, 2021,169: 105055
(4) Xiaoxue Wu(†), Xuemin Gao(†), Xinmei Liu, Shuyi Zhang, Huayu Yang, Xuan Zhu, Hua Song, Funan Li and Qing Chen*. Quality Control of Psoralea corylifolia L. Based on High-Speed Countercurrent Chromatographic Fingerprinting. Molecules, 2020, 25(2): 279-292
(5) Xiaoxue Wu(†) , Xuemin Gao(†), Xuan Zhu, Shuyi Zhang, Xinmei Liu, Huayu Yang, Hua Song and Qing Chen*. Fingerprint Analysis of Cnidium monnieri (L.) Cusson by High-Speed Counter-Current Chromatography. Molecules, 2019, 24(24): 4496-4510
(6) Yilin Chen(†)，Qing Chen(†)， Qixin Zhu, Jinxue Liu, Yang Li, Xuemin Gao, Dengyue Chen* and Xuan Zhu*. Small Molecular Theranostic Assemblies Functionalized by Doxorubicin−Hyaluronic Acid−Methotrexate Prodrug for Multiple Tumor Targeting and Imaging-Guided Combined Chemo-Photothermal Therapy. Molecular Pharmaceutics，2019, 16, 2470−2480
(7) Qing Chen (†), Xiaoxue Wu (†), Xuemin Gao, Hua Song (*) and Xuan Zhu (*), Development and validation of an Ultra-Performance Liquid Chromatography method for the determination of Wedelolactone in rat plasma and its application in a pharmacokinetic study, Molecules, 2019, 24(4): 762.
(8) Yu Zhou, Wushuang Yang, Zhiqun Li, Doudou Luo, Weijie Li, Yali Zhang, Xuan Wang, Meijuan Fang, Qing Chen(*), Xin Jin*, Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα, Biomedicine & Pharmacotherapy，2018, 107: 44-53
(9) Jing Wang (†), Hua Song (†), Xiaoxue Wu, Shuyi Zhang, Xuemin Gao, Funan Li, Xuan Zhu (*) and Qing Chen (*), Steroidal saponins from Vernonia amygdalina Del. and their biological activity, Molecules. 2018, 23(3): 579-589.
(10) Dan Zhao (†), Qing Chen(†), Hua Song*, Shuting Luo, Pingyun Ge, Yingjun Wang, Jinyuan Ma, Zhi Li, Xuemin Gao, Xuemei Zhao, Xiayiding Subinuer, Huayu Yang, Xiaojuan Jiang, Yanxin Chen, Xuan Zhu, Theranostic micelles combined with multiple strategies to effectively overcome multidrug resistance.Nanomedicine, 2018, 13(13): 1517-1533
(11) Yuxin Guo, Yang Zhang, Jinyuan Ma, Qi Li, Yang Li, Xinyi, Zhou, Dan Zhao, Hua Song, Qing Chen(*), Xuan Zhu*, Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics. Journal of Controlled Release, 2018,272: 145-158
(12) Guihua Liu, Jinyuan Ma, Yang Li, Qi Li, Chunhua Tan, Hua Song, Shuhui Cai, Dengyue Chen, Zhengqing Hou, Qing Chen(*), Xuan Zhu*, Core-interlayer-shell Fe3O4@mSiO2@lipid-PEG-methotrexate nanoparticle for multimodal imaging and multistage targeted chemo-photodynamic therapy. International Journal of Pharmaceutics, 2017, 521(1-2):19–32
(13) Qing Chen, Lichao Diao, Hua Song, Xuan Zhu*, Vitis amurensis Rupr: A review of chemistry and pharmacology, Phytomedicine, 2018,49：111-122
(14) Hua Song，Jianhong Lin，Xuan Zhu，Qing Chen (*)，Developments in high-speed countercurrent chromatography and its applications in the separation of terpenoids and saponins，Journal of Separation Science, 2016, 39(8) : 1574-1591
(15)Jing Lin, Hongjie Wu, Yingjun Wang, Jianhong Lin, Qing Chen (*), Zhu Xuan(*) , Preparation and ocular pharmacokinetics of hyaluronan acid-modified mucoadhesive liposomes, Drug Delivery, 2016, 23(4) : 1144-1151
(16) Chen Qing，Lin Jianhong，Zhao Dan，Zhu Xuan(*)， Isolation and Stucture Elucidation of Diterpenes from Wedelia prostrata and Their Cytotoxicity Activities，Chemical Research in Chinese Universities，2016，32(5): 792-796
(17) Qing Chen, JianguangLuo, Lingyi Kong*. New triterpenoid saponins from the roots of Gypsophila perfoliata Linn. Carbohydrate Research, 2011, 346(14): 2206-2212
(18) Qing Chen, Jianguang Luo and Lingyi Kong*. Triterpenoid Saponins from Gypsophila altissima L. Chemical & Pharmaceutical Bulletin, 2010, 58(3): 412-414
(19) Qing Chen, Shun Yao, Xuefeng Huang, JianguangLuo, Junsong Wang, Lingyi Kong*. Supercritical fluid extraction of Coriandrum sativum and subsequent separation of isocoumarins by high-speed counter-current chromatography. Food Chemistry, 2009, 117 (3): 504-508
Email: chenqing@xmu.edu.cn
