Chao Liu,  Ph.D.

Associate Professor

School of Pharmaceutical Science, Xiamen University, Xiang’an South Road, Xiamen, P. R. China, 361002

E-mail            liuchao66888@xmu.edu.cn

Experience

2022-present      Associate Professor, School of Pharmaceutical Science, Xiamen University    

2020-2022      Postdoctoral Researcher, School of Public Health, Xiamen University    

2016-2020       Ph.D., School of Public Health, Xiamen University

Research

Cancer immunotherapy, personalized vaccine system design, preparation, and functional evaluation, functional targeting delivery system construction based on bionics, and engineering virus vector transformation based on epigenetics.

1. Design of functionalized anti-tumor/viral vaccines;

2. Immune co-stimulation signal delivery platform;

3. Induction and reversal of T cell immune tolerance and regulation of tumor microenvironment.

Selected  Publications (last 5 years):

(*: corresponding author; #: equal contribution)

(1)Chao Liu#, Xue Liu#, Xinchu Xiang, Xin Pang, Siyuan Chen, Yunming Zhang, En Ren, Lili Zhang, Xuan Liu, Peng Lv, Xiaoyong Wang, Wenxin Luo, Ningshao Xia, Xiaoyuan Chen*, Gang Liu*. A Nanovaccine for Antigen Self-presentation and Immunosuppression Reversal as a Personalized Cancer Immunotherapy Strategy. Nature Nanotechnology, 2022, 17, 531-540.（IF=40.523）

News&Views: Yahya Mohammadzadeh, Michele De Palma*. Boosting dendritic cell nanovaccines. Nature Nanotechnology, 2022, 17, 442-444.

(2) Xue Liu#, Chao Liu#, Zizheng Zheng#, Siyuan Chen, Xin Pang, Xinchu Xiang, Jixian Tang, En Ren, Yuanzhi Chen, Min You, Xiaoyong Wang, Xiaoyuan Chen, Wenxin Luo*, Gang Liu*, Ningshao Xia*. Vesicular Antibodies: A bioactive multifunctional combination platform for targeted therapeutic delivery and cancer immunotherapy, Advanced Materials. 2019, 31(17), 201808294.（IF=32.086）

(3) Shuyu Xu, Xiaoxiao Shi, En Ren, Jianzhong Zhang, Xing Gao, Dan Mu, Chao Liu*, and Gang Liu*. Genetically engineered nanohyaluronidase vesicles: a smart sonotheranostic platform for enhancing cargo penetration of solid tumors. Advanced Functional Materials. 2022, 32(22):202112989.（IF=19.924）

(4) Xiaoxiao Shi, Yang Zhang, Shuyu Xu, Shuang Bai, Xue Liu, Yonghe Jiang, Chao Liu*, and Gang Liu *. Unimolecule-based Size-charge Switchable Nanomedicine for Deep Cancer Sono-immunotherapy. Nano Today. 2022, 43, 101417.（IF=18.962）

(5) Jingyi Liu#, Chao Liu#, Jinfeng Zhang#, Yunming Zhang, Keyin Liu, Ju-Xian Song, Sravan Gopalkrishnashetty Sreenivasmurthy, Ziying Wang, Yesi Shi, Chengchao Chu, Yang ZhangCai, sheng Wu, Xianhua Deng, Xingyang Liu, Jing Song, Rongqiang Zhuang, Shuqiong Huang, Pengfei Zhang, Min Li*, Lei Wen*, Yun wu Zhang, Gang Liu*. A self-assembled α-synuclein nanoscavenger for parkinson’s disease. ACS Nano. 2020, 14(2): 1533-1549.（IF=18.027）

(6) En Ren#, Chao Liu#, Peng Lv, Junqing Wang*, Gang Liu*. Genetically Engineered Cellular Membrane Vesicles as Tailorable Shells for Therapeutics. Advanced Science. 2021, 8(21): 202100460.（IF=17.521）

(7) Xue Liu#, Chao Liu#, Gang Liu, Wenxin Luo*, and Ningshao Xia. COVID-19: Progress in diagnostics, therapy and vaccination. Theranostics. 2020, 10(17):7821-7835.（IF=11.6）

(8) Jianzhong Zhang#, Xue Liu#, Yutian Xia, Shuyu Xu, Xuan Liu, Haiqing Xiao, Xiaoyong Wang, Chao Liu*, Gang Liu. Genetically engineered nano-melittin vesicles for multimodal synergetic cancer therapy. Bioengineering & Translational Medicine. 2023, e10482.（IF=10.684）

(9) Yesi Shi#, Gan Lin#, Huili Zheng#, Dan Mu, Hu Chen, Zhixiang Lu, Pan He, Yang Zhang, Chao Liu*, Zhongning Lin*, Gang Liu* Biomimetic Nanoparticles Blocking Autophagy for Enhanced Chemotherapy and Metastasis Inhibition via Reversing Focal Adhesion Disassembly. Journal of Nanobiotechnology. 2021, 19(1):447.（IF=9.429）

(10) Xiaoqing Chen#, Xue Liu#, Yichao Jiang, Ningshao Xia, Chao Liu* and Wenxin Luo*. Abnormally primed CD8 T cells: The Achilles’ heel of CHB. Frontiers in Immunology. 2023.（IF=8.786）

(11)Shuo Li, Xue Liu, Gang Liu*, Chao Liu*. Biomimetic nanotechnology for SARS-CoV-2 treatment. Viruses. 2023, 15(3):596.（IF=5.818）

(12) Shuaiying Wu#, Chao Liu#, Shuang Bai, Zhixiang Lu*, Gang Liu *. Broadening the Horizons of RNA Delivery Strategies in Cancer Therapy. Bioengineering. 2022, 9(10): 576.（IF=5.046）

(13) Chao Liu, Haiyan Gao, Peng Lv, Jingyi Liu, Gang Liu*. Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics. Human Vaccines & Immunotherapeutics. 2017, 13(11), 2678-2687.（IF=4.526）

(14) Wei Xiang#, Xue Liu#, Lili Zhang, Chao Liu*, Gang Liu*. Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy. Particuology. 2022, 64, 35-42.（IF=3.251）