Liang-cheng Li, Ph.D.

Associate Professor

Experience

Dr. Li received his bachelor degree from Chinese Agricultural University, his master degree from Northwest Plateau Institute of Biology, Chinese Academy of Sciences, and Ph.D. degree from Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College in China. In 2002, He went to USA joined Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey as a Research Fellow, and in 2005, he joined Department of Microbiology & Immunology, School of Medicine, University of Illinois at Chicago as research associate and research scientist, respectively. He was recruited to Xiamen University as associate professor of the school of pharmaceutical sciences since 2013.

Research

Dr. Li's group is focusing on investigating the etiology of cancer and diabetes mellitu aimed to developing the therapeutic strategies and agents for cure of these diseases. More specifically, there are two research groups in his lab: 1): in cancer research group, there are focusing on investigation the etiology of cancer, like liver cancer, colon cancer, breast cancer and ovarian cancer, and trying to identify the biomarker for development the diagnosis kits for early detection and the novel leads for cure of cancer. 2) in diabetic research group, they have mainly focused on, either in functional recovery of pancreatic islets or in endogenous regeneration of damaged pancreatic islets.

Selected Publications (last 5 years):

1. Zhang, SM., Huang, FR., Tian, WJ., Lai, JF., Qian, LX., Hong, WJ. ^*, Chen, HF. ^*, Li, L-C*. Andrographolide promotes PANC-1 Differentiation into Insulin-producing Cells. Biochemical Pharmacology.2020, 174:113785.

2. Zhou,YX., Liu, ZY., Zhang,SM., Zhuang,RJ., Liu,HY., Liu, XQ., Qiu, X., Zhang,M., Zheng, YP., Li, L-C., Wanjin Hong,W*., and Wang., TL*. RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin. Diabetes 2020 Jan;69(1):67-82.

3. Li, LH., Guo, QY., Liu, YX., Lu, MD., Yang, J., Ge, YL., Zhang, Q., Sun, BQ., Wang, XM., Li, L-C., Ren L. Targeted combination therapy for glioblastoma by co-delivery of doxorubicin, YAP-siRNA and gold nanorods. Journal of Materials Science & Technology. 2020, https://doi.org/10.1016/j.jmst.2020.03.009.

4. Li, L-C., Wang, Y., Carr, R., Haddad, Li, Z., Qian, L-X., Oberholzer, J., Maker, AV., Wang, Q., Prabhakar, BS., IG20/MADD Plays a Critical Role in Glucose-Induced Insulin Secretion. Diabetes. 2014 May;63(5):1612-23.

5. Jayarama, S, Li, L-C^#, Ganesh, L., Mardi, PK., Hay, N., Li, PF., Prabhakar, BS. MADD is a downstream target of PTEN in triggering apoptosis. J. Cell. Biochem. 2014, 115 (2): 261-70.

6. Li, L-C, Jayarama, S., Pilli T., Qian, L-X. , Ganesh, L., Pacini, F., Prabhakar, BS^(*)., Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand. Thyroid, 2013, 23(1):70-8.

7. Li, L-C. Jayarama, S., Ganesh, L., Qian, L-X., Rotmensch, J., Prabhakar, BS., Knockdown of MADD and c-FLIP overcome resistance to TRAIL-induced apoptosis in ovarian cancer cells.Am J Obstet Gynecol. 2011, 205(4): 362.e12-25.

8. Li, L-C., Sheng, JR, Mulherkar, N., Prabhakar, BS., Meriggioli MN. Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoform of the IG20 gene. Cancer Res. 2008;15;68(18):7352-61.

Tel: +86-592-288-1126

Fax: +86-592-218-1879

Email: lcli2013 at xmu.edu.cn