Xiaosheng Yan, Ph.D.

 Associate Professor

 Email: xshyan@xmu.edu.cn

 Xiaosheng Yan obtained his Bachelor’s degree in applied chemistry from Huazhong Agricultural University in 2010, and his PhD degree in analytical chemistry from Xiamen University in 2016 under the supervision of Professor Yun-Bao Jiang.From 2016 to 2021, he worked as a postdoctoral researcher and then a research assistant at Xiamen University. He joined the School of Pharmaceutical Sciences of Xiamen University as an associate professor in 2021. His research interests are centered on biomedical applications of assembled materials from peptides, recognition/delivery/resolution of chiral drugs, and halogen/chalcogen bonds in drug discovery.

Selected Publications (last 5 years):

 1. Xiaosheng Yan, Kunshan Zou, Jinlian Cao, Xiaorui Li, Zhixing Zhao, Zhao Li, Anan Wu, Wanzhen Liang, Yirong Mo, and Yunbao Jiang*. Single-handed supramolecular double helix of homochiral bis(N-amidothiourea) supported by double crossed C−I···S halogen bonds. Nat. Commun.2019, 10, 3610. (Editors’ highlights)

 2. Xiaosheng Yan, Qian Wang, Xuanxuan Chen, and Yun-Bao Jiang*. Supramolecular Chiral Aggregates Exhibiting Nonlinear CD–ee Dependence. Adv. Mater. 2020, 32, 1905667.

 3. Xiang Lin, Bohan Kou, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li,* and Yun-Bao Jiang*. Spontaneous Resolution of Helical Building Blocks through the Formation of Homochiral Helices in Two Dimensions. Angew. Chem. Int. Ed.2022, 61, e202205914.

 4. Peimin Weng, Xiaosheng Yan,* Jinlian Cao, Zhao Li and Yun-Bao Jiang*. Intramolecular chalcogen bonding to tune the molecular conformation of helical building blocks for a supramolecular helix. Chem. Commun.2022, 58, 6461−6464.

 5. Qingqing Fang, Yan Xu, Xiaosheng Yan,* Tao Jiang,* and Yunbao Jiang*. Synthetic approaches to metal-coordination-directed macrocyclic complexes. Front. Chem.2022, 10, 1078432.

 6. Zhixing Zhao, Bailing Tang, Xiaosheng Yan,* Xin Wu,* Zhao Li, Philip A. Gale,* and Yun-Bao Jiang*. Crown ether-thiourea conjugates as ion transporters. Front. Chem. Sci. Eng.2022, 16, 81−91.

 7. Xiaosheng Yan,* Peimin Weng, Di Shi and Yun-Bao Jiang*. Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions. Chem. Commun.2021, 57, 12562−12574. (Inside cover)

 8. Xiaosheng Yan,^† Jinlian Cao,^† Yanhan Zhang, Peimin Weng, Daiyu Miao, Zhixing Zhao, Zhao Li and Yun-Bao Jiang*. Solvophobic interaction promoted supramolecular helical assembly of building blocks of weak intermolecular halogen bonding. Chem. Commun.2021, 57, 1802−1805. (^†Equal contribution)

 9. Di Shi, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals. Org. Biomol. Chem.2021, 19, 6397−6401. (Editor’s Collection)

 10. Zhixing Zhao, Miaomiao Zhang, Bailing Tang, Peimin Weng, Yueyang Zhang, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Transmembrane Fluoride Transport by a Cyclic Azapeptide With Two β-Turns. Front. Chem.2021, 8, 621323.

 11. Yanhan Zhang,^†Xiaosheng Yan,^† Jinlian Cao, Peimin Weng, Daiyu Miao, Zhao Li, and Yun-Bao Jiang*. Turn Conformation of β-Amino Acid-Based Short Peptides Promoted by an Amidothiourea Moiety at C-Terminus. J. Org. Chem.2020, 85, 9844−9849. (^†Equal contribution)