Hongchen Cai, Ph.D.
Professor
Experience
Xiamen University | Xiamen, Fujian, China |
Principle Investigator | 2022.12-present |
Stanford University | Stanford, CA, USA |
Postdoctoral Fellow | 2017.07-2022.11 |
Advisor: Dr. Monte Winslow and Dr. Dmitri Petrov
The Pennsylvania State University | University Park, PA, USA |
Ph.D., Molecular, Cellular and Integrative Biosciences | 2011.08-2017.05 |
Advisor: Dr. Aimin Liu
Tsinghua University | Beijing, China |
M.S., Biology | 2008.09-2011.06 |
Advisor: Dr. Yong-Bin Yan
Tsinghua University | Beijing, China |
B.S., Biological Science | 2004.08-2008.07 |
Research
Lung cancer is the leading cause of global cancer deaths. The vast number of functionally unclear mutated genes represent a huge gap in understanding lung cancer. We use Genetically engineered mouse models (GEMMs), CRISPR/Cas9-mediated somatic gene editing andtumor-barcoding and ultradeep barcode sequencing (Tuba-seq) to fill the gap. We aim inadvancing mouse models and systematic and quantitative approaches, and unraveling the molecular and geneticmechanisms of cancer.
Selected Publications (last 5 years):
Hongchen Cai*, Su Kit Chew*, Chuan Li*, Min K. Tsai, Laura Andrejka, Christopher W Murray, Nicholas W. Hughes, Emily G. Shuldiner, Emily L. Ashkin, Rui Tang, King L. Hung, Leo C. Chen, Shi Ya C. Lee, Maryam Yousefi, Wen-Yang Lin, Christian A. Kunder, Le Cong, Christopher D. McFarland, Dmitri A. Petrov, Charles Swanton and Monte M. Winslow. A functional taxonomy of tumor suppression in KRAS-driven lung cancer. Cancer Discovery.2021 Jul;11(7):1754-1773. doi: 10.1158/2159-8290.CD-20-1325. PMID: 33608386. *Co-first authors.
Giorgia Foggetti*, Chuan Li*, Hongchen Cai*, Jessica A Hellyer, Wen-Yang Lin, Deborah Ayeni, Katherine Hastings, Jungmin Choi, Anna Wurtz, Laura Andrejka, Dylan G. Maghini, Nicholas Rashleigh, Stellar Levy, Robert Homer, Scott N. Gettinger, Maximilian Diehn, Heather A. Wakelee, Dmitri A. Petrov, Monte M. Winslow and Katerina Politi. Genetic determinants of EGFR-driven lung cancer growth and therapeutic response in vivo. Cancer Discovery.2021 Jul;11(7):1736-1753. doi: 10.1158/2159-8290.CD-20-1385. PMID: 33707235. *Co-first authors.
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M. E. Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow and Julien Sage. A multiplexed in vivo gene knockout approach to identify cancer drivers in small cell lung cancer. Cell Reports.2023 Jan 31;42(1):111990. doi: 10.1016/j.celrep.2023.111990.PMID: 36640300
Tel: +86-592-
Fax: +86-592-
Email: caihc@xmu.edu.cn
