MEI-JUAN FANG, Ph.D.
Associate Professor
Nationality P. R. China
Address School of Pharmaceutical Science, Xiamen University
Xiang’an South Road, Xiamen, P. R. China, 361002
Phone +86-592-2189868 (O)
E-mail fangmj@xmu.edu.cn
Experience
2011-present Associate Professor, School of Pharmaceutical Science, Xiamen University
2014-2015 Associate researcher, Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF)
2006-2011 Assistant Professor of Medicinal Chemistry, Department of Pharmaceutical Sciences, Medical College, Xiamen University
2001-2006 Graduate Student in Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University (Advisor: Prof. Yufen Zhao)
Research
Dr. Fang's research focuses on developing novel bioactive small molecules targeting nuclear receptors (Nur77, RXRα, RARγ) and cyclin dependent kinase (CDKs) for treating diseases, including cancer, HIV, and other inflammatory diseases. Her second area of interest is the application of omics in drug development. Dr. Fang has published over 50 papers in SCI journals (European Journal of Medicinal Chemistry, Chinese Chemical Letters, Journal of Enzyme Inhibition and Medicinal Chemistry, Bioorganic Chemistry,Organic Chemistry Frontiers, Advanced Synthesis & Catalysis, et al.) and holds several Chinese patents.
Selected Publications (last 5 years):
1. Jun Chen#, Taige Zhao#, Fengming He, Yijing Zhong, Susu Wang, Ziqing Tang, Yingkun Qiu, Zhen Wu*, Meijuan Fang*. Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy. European Journal of Medicinal Chemistry 254 (2023) 115341.
2. Hua Fang#, Yin Cao#, JianYu Zhang, Xiumei Wang, Mengyu Li, Zhuan Hong, Zhen Wu, Meijuan Fang*. Lipidome Remodeling Activities of DPA-EA in Palmitic Acid-Stimulated HepG2 Cells and The in vivo Anti-obesity Effect of the DPA-EA and DHA-EA Mixture Prepared from Algae Oil. Frontiers in Pharmacology. 2023, 14:1146276.
3. Fengming He#, Xiumei Wang#, Qiaoqiong Wu, Shunzhi Liu, Yin Cao, Xiaodan Guo, Sihang Yin, Na Yin, Baicun Li*, Meijuan Fang*, Identification of potential ATP-competitive cyclin-dependent kinase 1 inhibitors: De novo drug generation, molecular docking, and molecular dynamics simulation. Computers in Biology and Medicine 155 (2023) 106645.
4. Mingtao Ao#, Jun Wu#, Yin Cao, Yaohui He, Yuxiang Zhang, Xiang Gao, Yuhua Xue*, Meijuan Fang*, Zhen Wu*, The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9. Chinese Chemical Letters 34 (2023) 107741.
5. Haofan Zhang#, Fengming He#, Guiping Gao, Sheng Lu, Qiaochu Wei, Hongyu Hu, Zhen Wu, Meijuan Fang*, and Xiumin Wang*, Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling. Molecules 2023, 28, 943. https://doi.org/10.3390/molecules28030943.
6. Qingbo Qin#, Xiaohui Chen#, Weihao Liu#, Jun Chen, Weirong Liu, Yongzhen Xia , Zhehui Li, Mingyu Li, Shaojuan Wang, Quan Yuan, Yingkun Qiu*, Zhen Wu*, Meijuan Fang*, Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agentstargeting Nur77. European Journal of Medicinal Chemistry 244 (2022) 114849.
7. Yuqing Qian#, Mingtao Ao#, Boqun Li#, Zhijian Kuang, Xiumei Wang, Yin Cao, Jiayi Li, Yingkun Qiu, Kaiqiang Guo*, Meijuan Fang*, Zhen Wu*. Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors. Bioorganic Chemistry 129 (2022) 106119. (SCI, 5.307)
8. Fengming He#, Wang Cong#, Cao Yin, Chenfan Li, Shengxian Zhao, Zhen Wu, Hongyu Hu*, Meijuan Fang*. Design, synthesis, and biological evaluation of (E)-N‘-substitute-4-((4-pyridylpyrimidin-2-yl)amino) benzohydrazide derivatives as novel potential CDK9 inhibitors. Arabian Journal of Chemistry (2022) 15, 104039.
9. Hua Fang, Mengyu Li, Hui Chen, Jun Chen, Zhuan Hong, Weizhu Chen*, Meijuan Fang*. Study on Salicylanilide Analogue for Antioxidant Activity and Melanosis Prevention in Chinese White Shrimp (Fenneropenaeus chinensis), Journal of Aquatic Food Product Technology, 2022, 31(5): 410-417. DOI: 10.1080/10498850.2022.2059425.
10. Baicun Li#, Jiangang Huang#, Jie Liu#, Fengming He, Fangfang Wen, Changming Yang, Wang Wang, Tong Wu, Taige Zhao, Jie Yao, Shunzhi Liu, Yingkun Qiu, Meijuan Fang*, Jinzhang Zeng*, Zhen Wu*. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorganic Chemistry 121 (2022) 105651.
11. Mingtao Ao#, Jianyu Zhang#, Yuqing Qian#, Boqun Li, Xiumei Wang, Jun Chen, Yuxiang Zhang, Yin Cao, Yingkun Qiu, Yang Xu*, Zhen Wu* and Meijuan Fang*. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorganic Chemistry 120 (2022) 105645.
12. Jun Wu#, Hongyu Hu#, Mingtao Ao#, Zhenzhen Cui, Xiaoping Zhou, Jingbo Qin, Yafei Guo, Jingwei Chen*, Yuhua Xue* and Meijuan Fang*. Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl) amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a novel and selective anticancer agent. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36(1), 1436–1453.
13. Mingtao Ao#, Xianwen Hu#, Yuqing Qian#, Boqun Li, Jianyu Zhang, Yin Cao, Yuxiang Zhang, Kaiqiang Guo, Yingkun Qiu, Fuquan Jiang*, Zhen Wu*, Meijuan Fang*. Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities. Bioorganic Chemistry 113 (2021) 104961.
14. Baicun Li#, Jie Yao#, Fengming He#, Jie Liu, Zongxin Lin, Shunzhi Liu, Wang Wang, Tong Wu, Jiangang Huang, Kun Chen, Meijuan Fang*, Jingwei Chen*, Jin-Zhang Zeng*. Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer. Bioorganic Chemistry 113 (2021) 105008.
15. Jun Wu, Yafei Guo, Jun Chen, Sangsang Hu, Ke Sun, Hongyu Hu*, Meijuan Fang* and Yuhua Xue*. Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives. Chem. Biodiversity 2021, 18, e202100671.
16. Jingbo Qin#, Jie Liu#,, Chunxiao Wu, Jianwen Xu, Bowen Tang, Kaiqiang Guo, Xiaohui Chen, Weihao Liu, Tong Wu, Hu Zhou*, Meijuan Fang*, Zhen Wu*. Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRα antagonists. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35(1), 880–896.
17. Hua Fang, Jianyu Zhang, Mingtao Ao, Fengming He, Weizhu Chen, Yuqing Qian, Yuxiang Zhang, Yang Xu*, Meijuan Fang*. Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77. Bioorganic Chemistry 105 (2020) 104456.
18. Hua Fang, Honghui Guo, Hui Chen, Zhuan Hong∗,Meijuan Fang*. Novel derivatives of salicylanilide: Synthesis, characterization, PPO inhibitory activity and cytotoxicity. Journal of Molecular Structure, 2021, 1223, 128995.
19. Hongyu Hu#, Jun Wu#, Mingtao Ao#, Xiaoping Zhou, Boqun Li, Zhenzhen Cui, Tong Wu, Lijuan Wang, Yuhua Xua⁎, Zhen Wu⁎, Meijuan Fang*. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors. Bioorganic Chemistry 102 (2020) 104064.
20. Kaiqiang Guo#, Yin Cao#, Zan Li, Xiaoxiao Zhou, Rong Ding, Kejing Chen, Yan Liu, Yingkun Qiu, Zhen Wu*, Meijuan Fang*. Glycine metabolomic changes induced by anticancer agents in A549 Cells. Amino Acids, 2020, 5, 793~809.
21. Baicun Li#, Jie Yao#, Kaiqiang Guo#, Fengming He, Kun Chen, Zongxin Lin, Shunzhi Liu, Jiangang Huang, Qiaoqiong Wu, Meijuan Fang*, Jinzhang Zeng*, Zhen Wu*. Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. European Journal of Medicinal Chemistry 204 (2020) 112608.
22. Baicun Li#, Feifeng Zhu#, Fengming He#, Qingqing Huang, Xiaoguang Liu, Tong Wu, Taige Zhao, Yingkun Qiu, Zhen Wu, Yuhua Xue⁎, Meijuan Fang⁎. Synthesis and biological evaluations of N′-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents. Bioorganic Chemistry 96 (2020) 103592.
23. Hua Fang, Jianlin He, Tan Ran, Hui Chen, Wenhui Jin, Bowen Tang, Zhuan Hong⁎, and Meijuan Fang⁎. Synthesis, biological activities, and docking studies of D-pantolactone derivatives as novel FAS inhibitors. Bioorganic & Medicinal Chemistry. 2019, 27, 115069.
24. Guozhang Lu, Jun Chen, Xinlei Huangfu,a Xueyan Li, Meijuan Fang,* Guo Tang* and Yufen Zhao. Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus. Organic Chemistry Frontiers. 2019, 6(2): 190-194. DOI: 10.1039/c8qo01087k.
25. Shanshan Shi, Jun Chen, Shaohua Zhuo, Zi’ang Wu, Meijuan Fang,* Guo Tang,* and Yufen Zhao. Iodide-Catalyzed Phosphorothiolation of Heteroarenes Using P(O)H Compounds and Elemental Sulfur, Advanced Synthesis & Catalysis. 2019, 361, 3210–3216. DOI: 10.1002/adsc.201900291.
26. Bowen Tang#, Baicun Li#, Boqun Li, Jingbo Qin, Junming Zhao, Jianwenn Xu, Yingkun Qiu, Zhen Wu* and Meijuan Fang*. Insights into the Stereoselectivity of human SETD7 methyltransferase. RSC Advances, 2019, 9: 9218.
27. Hongyu Hu, Jun Wu, Jianfeng Yuan, Zhenni Wang, Chenfan Li, Xiaoyan Yan, Meijuan Fang⁎ and Shengxian Zhao*, Synthesis and Biological Activity Research of 4-Substitued-1-(2-methyl-6-(pyridin-3-yl)-nicotinoyl) Semicarbazides, Chin. J. Org. Chem. 2019, 39, 2507～2514.
28. Mingtao Ao#, Zhenrui Pan#, Yuqing Qian#, Bowen Tang, Zeming Feng, Hua Fang, Zhen Wu, Jingwei Chen*, Yuhua Xue* and Meijuan Fang*, Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1. RSC Advances, 2018, 8: 17279-17292. DOI: 10.1039/c8ra01216d.
