Ling-juan Zhang, Ph.D.
Professor in Pharmacology
Experience
Dr. Zhang is a full professor at Xiamen University, School of Pharmaceutical Science, State key lab or cellular stress biology. She received her Ph.D. in Pharmacology at Oregon State University and post-doc training at the Department of Dermatology at the University of California, San Diego, where she continued as a Project Scientist before coming back to China. She is the associated editor of Experimental Dermatology and guest editor of SEMIN CELL DEV BIOL. She is also a broad member of several prestigious societies, including Chinese society of Skin Immunology and Chinese society of Investigative Dermatology.
Research
Area of expertise: Pharmacology, Dermatology, and Immunology.
Dr. Zhang’s research focuses on the function, regulatory mechanism, and drug target discovery of the innate immune system of the skin. Her work found that skin injury activates the dsRNA-MAVS-IFNβ innate immune pathway in keratinocytes to drive psoriasis pathogenesis, and she also discovered the innate immune antimicrobial function of dermal fibroblasts and adipocytes and its underlying regulatory mechanism during development, aging, wound healing and diet-induced obesity. She has published more than 40 paper in journals including Science (2015), Immunity (2016 and 2019), Science Translational Medicine(2021), Cell reports (2023), and Current Biology, with more than 3000 citations. Dr. Zhang’s current research focuses on exploring the interaction between dermal adipocyte lineage cells with immune cells and other skin resident cells, such as hair follicle cells. Results from these studies may lead to the development of novel therapeutic targets for treating skin infection, psoriasis, atopic dermatitis, chronic wounds, scar/keloids, and alopecia.
Selected Publications (*, co-responding author):
1. Ling-juan Zhang, Christian F. Guerrero-Juarez, Tissa Hata, Sagar P. Bapat, Raul Ramos, Maksim V. Plikus, Richard L. Gallo*. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science, 2015, Jan 2, 347(6217):67-71. doi: 10.1126/science.1260972.
2. Ling-juan Zhang, George L. Sen, Nicole L. Ward, Andrew Johnston, Kimberly Chun, Yifang Chen, Christopher Adase, James A. Sanford, Nina Gao, Melanie Chensee, Emi Sato, Yi Fritz, Jaymie Baliwag, Michael R. Williams, Tissa Hata, Richard L. Gallo*. Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury. Immunity, 2016 Jul 19;45(1):119-30. doi: 10.1016/j.immuni.2016.06.021.
3. Ling-juan Zhang*, Stella Xiang Chen, Christian F. Guerrero-Juarez Fengwu Li, Yun Tong, Yuqiong Liang, Marc Liggins, Xu Chen, Hao Chen, Min Li, Tissa Hata, Ye Zheng, Maksim V. Plikus, Richard L. Gallo*. Age-related loss of innate immune antimicrobial function of dermal fat is mediated by TGFβ. Immunity. 2019 Jan 15;50(1):121-136.e5. doi: 10.1016/j.immuni.2018.11.003.
4. Ling-juan Zhang*, Christian F. Guerrero-Juarez, Stella X. Chen, Xiaowei Zhang, Meimei Yin, Fengwu Li, Shuai Wu, Joyce Chen, Min Li, Yingzi Liu, Shang I. B. Jiang, Tissa Hata, Maksim V. Plikus, Richard L. Gallo*，Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors，20 January 2021，SCIENCE TRANSLATIONAL MEDICINE，13, eabb5280 (2021)， DOI：10.1126/scitranslmed.abb5280
5. Sun L, Zhang X, Wu S, Liu Y, Guerrero-Juarez CF, Liu W, Huang J, Yao Q, Yin M, Li J, Ramos R, Liao Y, Wu R, Xia T, Zhang X, Yang Y, Li F, Heng S, Zhang W, Yang M, Tzeng CM, Ji C, Plikus MV, Gallo RL, Zhang LJ*. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration. Cell Reports. 2023 Jun 16;42(6):112647. doi: 10.1016/j.celrep.2023.112647.
6. Yanhang Liao; Lixiang Sun; Jiacheng Li; Meifeng Nie; Xiaofen Huang; Shujun Heng; Wenlu Zhang; Tian Xia; Zhuolin Guo; Qinjian Zhao*; Ling-juan Zhang*. Modulation of skin inflammatory responses by aluminum adjuvant. Pharmaceutics, 2023, 15(2), 576; Published: 8 February 2023; doi.org/10.3390/pharmaceutics15020576
7. Ling-juan Zhangand Richard Gallo*. Antimicrobial peptides. Current Biology, 2016 Jan 11;26(1):R14-9. doi: 10.1016/j.cub.2015.11.017.
8. Xiaowei Zhang, Meimei Yin and Ling-juan Zhang*. Keratin 6, 16 and 17—Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis. Cells, 1 August 2019, 8(8), 807; doi:10.3390/cells8080807.
9. Jinwen Huang, Shujun Heng, Wenlu Zhang, Youxi Liu, Tian Xia, Chao Ji, and Ling-juan Zhang*, Dermal Extracellular Matrix molecules in skin development, homeostasis, wound regeneration and diseases, Seminars in Cell & Developmental Biology, 2022 Mar 23;S1084-9521(22)00064-7. doi: 10.1016/j.semcdb.2022.02.027.
10. Lixiang Sun, Wenjie Liu, and Ling-juan Zhang*. The role of toll-like receptors in skin host defense, psoriasis and atopic dermatitis. Journal of Immunology Research, 2019 Nov 14, Volume 2019, Article ID 1824624, 13 pages. https://doi.org/10.1155/2019/1824624.
11. Ling-juan Zhang*. Type1 interferons potential initiating factors linking skin wounds with psoriasis pathogenesis. Frontiers in Immunology, 2019 Jun 25;10:1440, doi: 10.3389/fimmu.2019.01440 2019.
12. Zhuolin Guo, Yichun Yang, Yanhang Liao, Yulin Shi, and Ling-juan Zhang*, Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity, JID Innovations,2021 Oct 13;2(1):100064. doi: 10.1016/j.xjidi.2021.100064.
13. Ling-juan Zhang*, Recent progress at the psoriasis and atopic dermatitis research front: An experimental dermatology perspective. Experimental Dermatology, 2021 Jun;30(6):756-764. doi: 10.1111/exd.14388
14. 孙礼祥，吴帅，张小薇，刘文杰，张凌娟*, 基于单细胞RNA测序探讨小鼠全层皮肤缺损创面中真皮成纤维细胞的生长因子调控网络，中华烧伤与创面修复杂志, 2022,38(7) : 629-639. DOI: 10.3760/cma.j.cn501225-20220215-00029
15. 周凡凡, 姚虔, 刘文杰, 张凌娟*. 皮肤共生菌在皮肤健康和疾病中的作用研究进展[J]. 微生物学通报, Mar. 20, 2022, 49(3): 1135−1146，DOI：10.13344/j.microbiol.china.210654 （Zhou Fanfan, Yao Qian, Liu Wenjie, Zhang Lingjuan. Emerging roles of commensal bacteria in skin health and diseases[J]. Microbiology China, Mar. 20, 2022, 49(3): 1135−1146）
16. Book chapter: Ling-juan Zhang*. Isolation, Culture and Characterization of Primary Mouse Epidermal Keratinocytes(Book chapter title). Mouse Cell Culture: Methods and Protocols (Springer Book Series), Ivan Bertoncello (Editor), Ed.; Springer, Humana Press: New York, NY, USA, 2019; Volume 1940, pp. 205–215. Published: Feb 21th. doi: 10.1007/978-1-4939-9086-3_15. （出版社：Springer）
17. Book chapter: Ling-juan Zhang*. Keratins in Skin Epidermal Development and Diseases. Keratin (Biochemistry Book Series). Published: November 5th 2018；DOI: 10.5772/intechopen.79050. ISBN 978-953-51-6296-4.（出版社：IntechOpen）
Tel: +86-592-2182453
Fax: +86-592-2182453
Email: Lingjuan.zhang@xmu.edu.cn
