Yang Xu, Ph.D.

Assistant Professor

Experience

1997-2002  Xi’an Jiaotong University, Department of Clinical Medicine, B.S.

2002-2005  Xi’an Jiaotong University, School of Medicine, Pathology and Pathophysiology, M.D.

2006-2010  The University of Hong Kong, School of Biological Sciences, Ph.D.

2010-present  Assistant Professor, School of Pharmaceutical Science, Xiamen University, China

Research

Our research mainly focuses on: 1) the regulation of mitochondria function and dynamics in physiological and pathological conditions; 2) the role of nuclear receptors in the regulation of alpha and beta cells functions; 3) the cellular signal transductions via the omics-approach.

Team

Selected Publications (last 5 years):

(1) Yang Xu; Juanjuan Tian; Qi Kang; Hang Yuan; Chengdong Liu; Zhehui Li; Jie Liu; Mingyu Li; Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish, Frontiers in Endocrinology, 2022, 13

(2) Mingtao Ao; Jianyu Zhang; Qian Yuqing; Baicun Li; Xiumei Wang; Jun Chen; Yuxiang Zhang; Yin Cao; Yingkun Qiu; Yang Xu; Zhen Wu; Mei-Juan Fang ; Design and synthesis of adamantyl substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo, Bioorganic Chemistry, 2022, 120: 105645-105645

(3) Sihan Ma; Lin Wang; Zongjunlin Liu; Xian Luo; Zonglang Zhou; Jun Xie; Yipeng Li; Shuo Cong; Min Zhou; Yang Xu; Guang Ran; One stone, two birds: engineering 2-D ultrathin heterostructure nanosheet BiNS@NaLnF(4) for dual-modal computed tomography/magnetic resonance imaging guided, photonic synergetic theranostics, Nanoscale, 2021, 13(1): 185-194

(4) Hua Fang; Jianyu Zhang; Mingtao Ao; Fengming He; Weizhu Chen; Yuqing Qian; Yuxiang Zhang; Yang Xu; Meijuan Fang ; Synthesis and discovery of omega-3 polyunsaturated fatty acidalkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77, Bioorganic Chemistry, 2020, 105: 104456-（13）

(5) Ji Xia; Qiang Luo; Shengbin Huang; Fuquan Jiang; Lin Wang; Guanghui Wang; Jingjing Xie; Jie Liu; Yang Xu ; Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signalinginitiated G(1) cell cycle arrest and apoptosis: A quantitative proteomic study, Chinese Journal of Cancer Research, 2019, 31(2): 375-388

Tel: +86-592-

Fax: +86-592-

Email:  xu_yang@xmu.edu.cn