Yun-Long Wu, Ph.D & Professor
Experience
2022-nowVice Dean, School of Pharmaceutical Sciences, Xiamen University, P. R. China
2019-nowProfessor, School of Pharmaceutical Sciences, Xiamen University, P. R. China
2014-2019 Associate Professor, School of Pharmaceutical Sciences, Xiamen University, P. R. China
2012-2014 Assistant Professor, School of Pharmaceutical Sciences, Xiamen University, P. R. China
2010-2012 Postdoctoral Fellow, Materials Sciences and Engineering, Nanyang Technological University, Singapore
2005-2011 PhD, Bioengineering, National University of Singapore, Singapore
2001-2005 Bachelor, Materials Chemistry, University of Science and Technology of China, P. R. China
Research
We focus on the development of novel drug/gene carriers based on injectable polymeric hydrogel, stimuli-responsive polymeric micelles, or cyclodextrin-based supramolecular nanostructures, for controllable drug delivery. So far, his personal H-index is 40 and he has published more than 100 SCI papers with >4500 citations.
Selected Publications (last 5 years):
1. Liu, M.; Luo, Z.; Li, Z.; Lai, X.; Loh, X. J.; Wu, C.*; Li, Z.*; Wu, Y.-L.* “EngineeredCelastrol and Plasmid Co-Delivery for In Situ Expression and Targeted Mitochondrial Relocation of Nur77 Protein Towards Effective Drug Resistance Reversion.”Chemical Engineering Journal, 2023, 453: 139879. (SCI impact factor: 16.744)
2. Han, Y.; Jiang, L.; Xu, C.; Liu, M.; Li, Q.; Zheng, L.; Chi, H.; Wang, X.; Liu, Z.; You, M.; Loh, X. J.; Wu, Y.-L.*; Li, Z.*; Li, C.* “Effectiveness of an Ocular Adhesive Polyhedral Oligomeric Silsesquioxane Hybrid Thermo-Responsive FK506 Hydrogel in a Murine Model of Dry Eye.”Bioactive Materials, 2022, 9: 77-91. (SCI impact factor: 16.874)
3. Fan, X.; Luo, Z.; Chen, Y.; Yeo, J. C. C.; Li, Z.*; Wu, Y.-L.*; He, C.* “Oxygen Self-Supplied Enzyme Nanogels for Tumor Targeting with Amplified Synergistic Starvation and Photodynamic Therapy.”Acta Biomaterialia, 2022, 142: 274-283. (SCI impact factor: 10.633)
4. Cheng, H.; Fan, X.; Ye, E.; Chen, H.; Yang, J.; Ke, L.; You, M.; Liu, M.; Zhang, Y.-W.; Wu, Y.-L.*; Liu, G.*; Loh, X. J.*; Li, Z.* “Dual Tumor Microenvironment Remodeling by Glucose-Contained Radical Copolymer for MRI Guided Photo-Immunotherapy.”Advanced Materials, 2022, 34(25): 2107674. (SCI impact factor: 32.086)
5. Ma, P.; Lai, X.; Luo, Z.; Chen, Y.; Loh, X. J.; Ye, E.; Li, Z.*; Wu, C*; Wu, Y.-L.* “Recent Advances in Mechanical Force-Responsive Drug Delivery Systems.” Nanoscale Advances, 2022, 4(17): 3462-3478. (SCI impact factor: 5.598)
6. Li, Z.; Fan, X.; Luo, Z.; Loh, X. J.; Ma, Y.; Ye, E.; Wu, Y.-L.*; He, C.*; Li, Z.* “Nanoenzyme-Chitosan Hydrogel Complex with Cascade Catalytic and Self-Reinforced Antibacterial Performance for Accelerated Healing of Diabetic Wounds.” Nanoscale, 2022, 14(40): 14970-14983. (SCI impact factor: 8.307)
7. Liu, M.; Chen, Y.; Zhu, Q.; Tao, J.; Tang, C.; Ruan, H.*; Wu, Y.*; Loh, X. J.* “Antioxidant Thermogelling Formulation for Burn Wound Healing.” Chemistry - An Asian Journal, 2022, 17(16): e202200396. (SCI impact factor: 4.839)
8. Yang, C.; Zhu, C.; Li, Y.; Li, Z.; Zhang, Z.; Xu, J.; Chen, M.; Li, R.; Liu, S.; Wu, Y.-L.*; Huang, Z.*; Wu, C.* “Injectable Selenium-Containing Polymeric Hydrogel Formulation for Effective Treatment of Myocardial Infarction.” Frontiers in Bioengineering and Biotechnology, 2022, 10: 912562. (SCI impact factor: 6.064)
9. Ma, P.; Jiang, L.; Luo, X.; Chen, J.; Wang, Q.; Chen, Y.; Ye, E.; Loh, X. J.; Wu, C.*; Wu, Y.-L.*; Li, Z.* “Hybrid Polydimethylsiloxane (PDMS) Incorporated Thermogelling System for Effective Liver Cancer Treatment.” Pharmaceutics, 2022, 14(12): 2623. (SCI impact factor: 6.525)
10. Chen, Y.; Ke, L.; Loh, X. J.*; Wu, Y.-L.* “Design and Gene Delivery Application of Polymeric Materials in Cancer Immunotherapy.” World Scientific Annual Review of Functional Materials, 2022, DOI: 10.1142/S2810922822300033.
11. Liu, M.; Wu, C.; Ke, L.; Li, Z.; Wu, Y.-L.*“Emerging Biomaterials-Based Strategies for Inhibiting Vasculature Function in Cancer Therapy.”Small Methods, 2021, 5(7): 2100347. (SCI impact factor: 15.367)
12. Li, Z.; Cheng, H.; Ke, L.; Liu, M.; Wang, C.-G.; Loh, X.; Li, Z.*; Wu, Y.-L.* “Recent Advances in New Copolymer Hydrogel-Formed Contact Lenses for Ophthalmic Drug Delivery.” ChemNanoMat, 2021, 7(6): 567-579. (SCI impact factor: 3.154)
13. Han, Y.; Xu, C.; Shi, H.; Yu, F.; Zhong, Y.; Liu, Z.; Loh, X. J.; Wu, Y.-L.*; Li, Z.*; Li, C.* “Engineered Bio-adhesive Polyhedral Oligomeric Silsesquioxane Hybrid Nanoformulation of Amphotericin B for Prolonged Therapy of Fungal Keratitis.”Chemical Engineering Journal, 2021, 421: 129734. (SCI impact factor: 13.273)
14. Wu, Y.-L.*; Li, Z.* “Recent Advances on Noninvasive Ocular Therapeutic Delivery Strategy Based on Polymeric Formulations.” Therapeutic Delivery, 2021, 12(6): 423-425.
15. Li, Z.; Liu, M.; Ke, L.; Wang, L.-J.; Wu, C*; Li, C.*; Li, Z.*; Wu, Y.-L.* “Flexible Polymeric Nanosized Micelle for Ophthalmic Drug Delivery: Research Progress in Recent Three Years.” Nanoscale Advances, 2021, 3(18): 5240-5254. (SCI impact factor: 5.598)
16. Jiang, X.; Li, Z.; Young, D. J.; Liu, M.; Wu, C.*; Wu, Y.-L.*; Loh, X.* “Towards the Prevention of Coronavirus Infection: What Role Can Polymers Play?” Materials Today Advances, 2021, 10: 100140. (SCI impact factor: 7.579)
17. Luo, Z.; Fan, X.; Chen, Y.; Lai, X.; Li, Z.*; Wu, Y.-L.*; He, C.* “Mitochondria Targeted Composite Enzyme Nanogels for Synergistic Starvation and Photodynamic Therapy.” Nanoscale, 2021, 13(42): 17737-17745. (SCI impact factor: 8.307)
18. Fan, X.; Ke, L.; Cheng, H.; Chen, H.; Li, Z.; Ye, E.*; Loh, X. J.; Wu, Y.-L.*; Liu, G.*; Li, Z.* “Enhanced Drug Retention by Anthracene Crosslinked Nanocomposites for Bimodal Imaging-Guided Phototherapy.” Nanoscale, 2021, 13(35): 14713-14722. (SCI impact factor: 8.307)
19. Fan, X.; Luo, Z.; Ye, E.*; You, M.; Liu, M.; Yun, Y.; Loh, X. J.; Wu, Y.-L.*; Li, Z.* “AuNPs Decorated PLA Stereocomplex Micelles for Synergetic Photothermal and Chemotherapy.” Macromolecular Bioscience, 2021, 21(7): 2100062. (SCI impact factor: 4.979)
20. Ma, P.; Chen, Y.; Lai, X.; Zheng, J.; Ye, E.; Loh, X. J.; Zhao, Y.; Parikh, B. H.; Su, X.*; You, M.*; Wu, Y.-L.*; Li, Z.* “The Translational Application of Hydrogel for Organoid Technology: Challenges and Future Perspectives.” Macromolecular Bioscience, 2021, 21(10): 2100191. (SCI impact factor: 4.979)
21. Ke, L.; Li, Z.; Fan, X.; Loh, X. J.; Cheng, H.*; Wu, Y.-L.*; Li, Z.* “Cyclodextrin-Based Hybrid Polymeric Complex to Overcome Dual Drug Resistance Mechanisms for Cancer Therapy.”Polymers, 2021, 13(8): 1254. (SCI impact factor: 4.329)
22. Chen, X.#; Wu, Y.-L.#; Chen, C.#; Gu, Y.; Zhu, C. Wang， S.; Chen, J.; Zhang, L.; Lv, L.; Zhang, G.; Yuan, Y.; Chai, Y.*; Zhu, M.*; Wu, C.* “Identifying Potential Anti-COVID-19 Pharmacological Components of Traditional Chinese Medicine Lianhuaqingwen Capsule Based on Human Exposure and ACE2 Biochromatography Screening.”Acta Pharmaceutica Sinica B, 2021, 11(1): 222-236. (SCI impact factor: 11.614)
23. Luo, Z.; Jiang, L.; Xu, C.; Kai, D.; Fan, X.; You, M.; Hui, C.M.; Wu, C.*; Wu, Y.-L.*; Li, Z.* “Engineered Janus Amphipathic Polymeric Fiber Films with Unidirectional Drainage and Anti-Adhesion Abilities to Accelerate Wound Healing.”Chemical Engineering Journal, 2021, 421: 127725. (SCI impact factor: 16.744)
24. Hu, B.; Berkey, C.; Feliciano, T.; Chen, X.; Li, Z.; Chen, C.; Amini, S.; Nai, M.H.; Lei, Q.-L.; Ni, R.; Wang, J.; Leow, W.R.; Pan, S.; Li, Y.-Q.; Cai, P.; Miserez, A.; Li, S.; Lim, C.T.*; Wu, Y.-L.*; Odom, T.W.*; Dauskardt, R.H.*; Chen, X.* ²Thermal-Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy.²Advanced Materials, 2020, 32(12): 1907030. (SCI impact factor: 32.086)
25. Ke, L.; Cai, P.; Wu, Y.-L.*; Chen, X.* ²Polymeric Nonviral Gene Delivery Systems for Cancer Immunotherapy.²Advanced Therapeutics, 2020, 3(6): 1900213. (SCI impact factor: 5.003)
26. Luo, Z.; Xue, K.; Zhang, X.; Lim, J. Y. C.; Lai, X.; Young, D. J.; Zhang, Z.-X.*; Wu, Y.-L.*; Loh, X. J.* ²Thermogelling Chitosan-Based Polymers for the Treatment of Oral Mucosa Ulcers.²Biomaterials Science, 2020, 8(5): 1364-1379. (SCI impact factor: 5.251)
27. Liu, Y.; Xu, C.; Fan, X.; Loh, X. J.; Wu, Y.-L.*; Li, Z.* ²Preparation of Mixed Micelles Carrying Folates and Stable Radicals Through PLA Stereocomplexation for Drug Delivery.²Materials Science and Engineering: C, 2020, 108: 110464. (SCI impact factor: 4.959)
28. Luo, Z.; Jiang, L.; Yang, S.; Li, Z.*; Soh, W. M. W.; Zheng, L.*; Loh, X. J.*; Wu, Y.-L.*²Light-Induced Redox-Responsive Smart Drug Delivery System by Using Selenium-Containing Polymer@MOF Shell/Core Nanocomposite.²Advanced Healthcare Materials, 2019, 8(15): 1900406. (SCI impact factor: 11.092)
29. Wu Y.-L.*; Li, Z* ²The Perspectives of Using Unimolecular Micelles in Nanodrug Formulation.²Therapeutic Delivery, 2019, 10(6): 333-335.
30. Liu, X.; Li, Z.; Loh, X.; Chen, K.; Li, Z.; Wu Y.-L.*²Targeted and Sustained Co-Release of Chemotherapeutics and Gene by Injectable Supramolecular Hydrogel for Drug-Resistant Cancer Therapy.²Macromolecular Rapid Communications, 2019, 40(5): 1800117. (SCI impact factor: 4.078)
31. Cheng, H.; Fan, X.; Wu, C.; Wang, X.; Wang, L.-J.; Loh, X.-J.*; Li, Z.*; Wu Y.-L.*²Cyclodextrin-Based Star-Like Amphiphilic Cationic Polymer as a Potential Pharmaceutical Carrier in Macrophages.²Macromolecular Rapid Communications, 2019, 40(5): 1800207. (SCI impact factor: 4.078)
32. Luo, Z.; Xu, Y.; Ye, E.; Li, Z.*; Wu, Y.-L.*²Recent Progress in Macromolecules Anchored Gold Nanoparticle Hybrid System for Therapeutic Applications.²Macromolecular Rapid Communications, 2019, 40(5): 1800029. (SCI impact factor: 4.078)
33. Chen, Y.-P.; Zhang, J.-L.; Zou, Y.; Wu, Y.-L.*²Recent Advances on Polymeric Beads or Hydrogels as Embolization Agents for Improved Transcatheter Arterial Chemoembolization (TACE).² Frontiers in Chemistry, 2019, 7: 408. (SCI impact factor: 3.782)
34. Xue, K.; Wang, X.; Yong, P. W.; Wu, Y.-L.*; Li, Z.*; Loh, X. J.* ²Hydrogels as Emerging Materials for Translational Biomedicine.² Advanced Therapeutics, 2019, 2(1): 1800088.
35. Luo, Z.; Jiang, L.; Ding, C.; Hu, B.; Loh, X. J.; Li, Z.*; Wu, Y.-L.*²Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelle for Effective Melanoma Treatments.²Advanced Healthcare Materials, 2018, 7(23): 1801221. (SCI impact factor: 11.092)
36. Cheng, H.; Fan, X.; Wang, X.; Ye, E.; Loh, X. J.*; Li, Z.*; Wu, Y.-L.*²Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Delivery of Chemotherapeutics to Drug Resistant Cancer Tumors.²Biomacromolecules, 2018, 19(6): 1926-1938. (SCI impact factor: 5.738)
37. Cheng, H.; Wu, Z.; Wu, C.; Wang, X.; Liow, S. S.;Li, Z.; Wu, Y.-L.* ²Overcoming STC2 Mediated Drug Resistance Through Drug and Gene Co-delivery by PHB-PDMAEMA Cationic Polyester in Liver Cancer Cells.²Materials Science and Engineering: C, 2018, 83: 210-217. (SCI impact factor: 5.080)
38. Chen, X.; Chen, Z.; Hu, B.; Cai, P.; Wang, S.; Xiao, S.; Wu, Y.-L.*; Chen, X.* ²Synergistic Lysosomal Activatable Polymeric Nanoprobe Encapsulating pH Sensitive Imidazole Derivative for Tumor Diagnosis.²Small, 2018, 14(9): 1703164. [Highlighted by Materials Views China: http://www.materialsviewschina.com/2018/02/27859/] (SCI impact factor: 9.598)
39. Fan, X.; Cheng, H.; Wang, X.; Ye, E.; Loh, X. J.; Wu, Y.-L.*; Li, Z.* ²Thermo-responsive Supramolecular Chemotherapy by “V”-shape Armed b-Cyclodextrin Star Polymer to Overcome Drug Resistance.² Advanced Healthcare Materials, 2018, 7(7): 1701143. (SCI impact factor: 11.092)
40. Wu, Y.-L.; Engl, W.; Hu, B.; Cai, P.; Leow, W. R.; Tan, N. S.; Lim, C. T.; Chen, X.* ²Nanomechanically Visualizing Drug-Cell Interaction at the Early Stage of Chemotherapy.²ACS Nano, 2017, 11(7): 6996-7005. (SCI impact factor: 13.942)
41. Cai, P.; Leow, W. R.; Wang, X.; Wu, Y.-L.*; Chen, X.* ²Programmable Nano-Bio Interfaces for Functional Biointegrated Devices.²Advanced Materials, 2017, 29(26): 1605529. [Featured as Inside Back Cover] [Highlighted by Materials Views China: http://www.materialsviewschina.com/2017/05/24998/] (SCI impact factor: 19.791)
42. Liu, X.; Chen, X.; Chua, M. X.; Li, Z.*; Loh, X. J.*; Wu, Y.-L.*²Injectable Supramolecular Hydrogels as Delivery Agents of Bcl-2 Conversion Gene for the Effective Shrinkage of Therapeutic Resistance Tumors.²Advanced Healthcare Materials, 2017, 6(11): 1700159. [Featured as Front Cover] [Highlighted by Advanced ScienceNews: http://www.advancedsciencenews.com/cover-art-featuring-cancer-therapy-angiogenesis-tissue-engineering/] [Highlighted by Materials Views China: http://www.materialsviewschina.com/2017/07/25828/] (SCI impact factor: 11.092)
43. Wang, X.; Liow, S. S.; Wu, Q.; Li, C.; Owh, C.; Li, Z.*; Loh, X. J.*; Wu, Y.-L.* ²Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.²Macromolecular Bioscience, 2017, 17(11): 1700186. (SCI impact factor: 3.238)
44. Li, Z.*; Liu, X.; Chen, X.; Chua, M. X.; Wu, Y.-L.*²Targeted Delivery of Bcl-2 Conversion Gene by MPEG-PCL-PEI-FA Cationic Copolymer to Combat Therapeutic Resistant Cancer.²Materials Science and Engineering: C, 2017, 76: 66-72. (SCI impact factor: 4.164)
45. Yang, D.-P.; Liu, X.; Teng, C. P.; Owh, C.; Win, K. Y.; Lin, M.; Loh, X. J.; Wu, Y.-L.*; Li, Z.; Ye, E.* ²Unexpected Formation of Gold Nanoflowers by a Green Synthesis Method as Agents for a Safe and Effective Photothermal Therapy.²Nanoscale, 2017, 9(41): 15753–15759. (SCI impact factor: 7.367)
46. Liow, S. S.; Dou, Q.; Kai, D.; Sugiarto S.; Yu, C. Y. Y.; Kwok, R. T. K.; Chen, X.; Wu, Y.-L.*; Ong, S. T.; Kizhakeyil, A.; Verma N. K.; Tang, B. Z.; Loh, X. J.* ²Long-term Real-time in vivo Drug Release Monitoring with AIE Thermogelling Polymer.²Small, 2017, 13(7): 1603404. [Featured as Back Cover] (SCI impact factor: 8.643)
47. Chen, X.; Qiu, Y.-K.; Owh, C.; Loh, X. J.*; Wu, Y.-L.*²Supramolecular Cyclodextrin Nanocarriers for Chemo- and Gene Therapy towards the Effective Treatment of Drug Resistant Cancers.²Nanoscale, 2016, 8(45): 18876-18881. (SCI impact factor: 7.367)
48. Wu, Y.-L.*; Wang, H.; Qiu, Y.-K.; Liow, S. S; Li, Z.; Loh, X. J.* ²PHB-based Gels as Delivery Agents of Chemotherapeutics for the Effective Shrinkage of Tumors.²Advanced Healthcare Materials, 2016, 5(20): 2679-2685. [Highlighted by http://www.advancedsciencenews.com/injectable-hydrogels-for-precise-chemotherapy/] (SCI impact factor: 11.092)
49. Wu, Y.-L.; Putcha, N.; Ng, K.W.; Leong, D.; Lim, C.T.; Loo, S.C.; Chen, X.* ²Biophysical Responses upon the Interaction of Nanomaterials with Cellular Interfaces.²Accounts of Chemical Research, 2013, 46(3):782-791. (SCI impact factor: 20.268)
50. Wu, Y.-L.; Li, J.*²Synthesis of Supramolecular Nanocapsules Based on Threading Multiple Cyclodextrins over Polymer on Gold Nanoparticles.²Angewandte Chemie International Edition, 2009, 48(21): 3842-3845. [Highlighted by Nature Asia-Pacific: http://www.nature.com/am/journal/2009/200908/full/am2009185a.html] (SCI impact factor: 11.994)
Email: wuyl@xmu.edu.cn
