Haifeng Chen,  Ph.D.

Professor, Deputy Dean

Experience

2022.07-now Professor, Deputy Dean, School of Pharmaceutical Sciences, Xiamen University

2013.08-2022.06 Professor, Assistant Dean, Director of Instrument Analysis and Testing Center, School of Pharmaceutical Sciences, Xiamen University

2010.08-2013.07    Associate Professor, Assistant Dean, Director of Instrument Analysis and Testing Center, School of Pharmaceutical Sciences, Xiamen University

2007.07-2010.08    Associate Professor, Institutes for Biomedical Research, Xiamen University,

2005.08-2007.07    Postdoctoral Fellow, Shenzhen Research Institute of Tsinghua University

2000.08-2005.07    PhD, College of Chinese Medicine, Natural product chemistry, Shenyang Pharmaceutical University

1996.08-2000.07    Bachelor, College of Chinese Medicine, Shenyang Pharmaceutical University

2012-2013, Visiting scholar, School of Pharmacy, China Medical University, Taiwan

2018-2019,Visiting scholar, School of Pharmacy, Case Western Reserve University, United States

Research

Our lab is mainly engaged in the research of active constituents from traditional Chinese medicine and natural products as well as the secondary research and development of traditional Chinese medicine.By using a variety of drug evaluation models related to serious diseases, more than 600 natural active compounds, including more than 150 new ones, were found from Fujian and Taiwan characteristic Chinese herbal, microbial and Marine resources. Among them, three molecules have entered the pre-clinical research stage as prototype or modified derivatives. We have published more than 60 academic papers in core journals and above, of which more than 40 are included in SCI. Applied for 15 invention patents, of which 11 were authorized. We are familiar with the laws of industrial development and technical needs of enterprises. We have assisted Shineway Pharmaceutical Co., LTD., Pien Tze Huang Pharmaceutical Co., LTD., Xiamen Traditional Chinese Medicine Factory Co., LTD., and other enterprises completing industrial project upgrading and product secondary development. As the executor, Prof. Chen has completed the preclinical pharmaceutical research of the National first-class Traditional Chinese medicine "GD79 Injection", the national six-class new medicine "Gualsankyu Macrostemon Granules" and "Maishuang Yinlu".

Team

Guanghui Wang, Ph.D, Associate Professor

Wenjing Tian, Ph.D. Assistant Professor

Selected Publications (last 5 years):

1. Wen-Jing Tian,* Mi Zhou , Da-Ren Qiu, Jun-Jie Chen, Xiang-Zhong Liu, Jing-Dian Li, Ting Lin, Guang-Hui Wang, Haifeng Chen* Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage. Bioorganic Chemistry 2022,128, 106088.

2. Xiangzhong Liu, Renjing Yang, Qiannan Xu, Mi Zhou, Jie Feng, Guanghui Wang, Ting Lin * ,Wenjing Tian * , Haifeng Chen *Tautomeric phytosterols from Vernonia amygdalina Delile and their anti-cervical cancer activity. Bioorganic Chemistry 2022,128, 106068.

3. Jie Feng, Fengming He, Yuhui Huang, Mi Zhou, Xiangzhong Liu, Xiansheng Ye, Renjing Yang,Wenjing Tian* and Haifeng Chen *. Inhibitory effects of phenolic glycosides from Trollius chinensis Bunge on α-glucosidase: inhibition kinetics and mechanisms. Food Function, 2022, 13, 2857.

4. Xiangzhong Liu, Mi Zhou, Shoulun He, Qiannan Xu, Chunchun Du, Honghong Zhu, Ting Lin, Guanghui Wang, Wenjing Tian *and Haifeng Chen *. Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity. Pharmaceuticals 2022, 15, 1160.

5. Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, and Hai-Feng Chen*. Synthesis and anti-hepatoma activities of U12 derivatives arresting G0/G1 phase and inducing apoptosis by PI3K/AKT/mTOR pathway. Pharmaceuticals, 2022, 15:107

6. Cong Wang^#, Huasong Lu^#, Xiangzhong Liu, Xiang Gao, Wenjing Tian, Haifeng Chen*, Yuhua Xue*, and Qiang Zhou*.A natural product targets BRD4 to inhibit phase separation and gene transcription. iScience, 2022, 25, 103719

7. Xiangzhong Liu†, Mi Zhou†, Chunchun Du, Honghong Zhu, Xi Lu, Shoulun He, Guanghui Wang, Ting Lin, Wenjing Tian*, Haifeng Chen*. Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response. Biomedicines. 2021, 9, 1473

8. Junjie Chen, Wenjing Tian, Ye Yun, Yingpu Tian, Cuiling Sun, Rong Ding, Haifeng Chen*. A discussion on the affecting factors of the fitting procedures’ reliability in isothermal titration calorimetry analysis. Archives of Biochemistry and Biophysics. 2021,713, 109045.

9. Chunlan Xie, Qingmei Liu, Zhihui He, Yingbao Gai, Zhengbiao Zou, Zongze Shao, Guangming Liu, Haifeng Chen*, Xianwen Yang*. Discovery of andrastones from the deep-sea-derived Penicillium allii-sativi MCCC 3A00580 by OSMAC strategy. Bioorganic Chemistry, 2021,108:104671

10. Xiansheng Ye, Wenjing Tian, Xiangzhong Liu, Mi Zhou, Dequan Zeng, Ting
Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities. Natural Product Research. 2021,doi.org/10.1080/14786419.2021.1892099

11. Yanlan Yang#, Mi Zhou#, Dongni Wang, Xiangzhong Liu, Xiansheng Ye, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk1Pathway. Journal of Natural Products, 2021, 82:339-351

12. Chunlan Xie#, Duo Zhang#, Ting Lin, Zhihui He, Qingxiang Yan, Qi Cai, Xiaokun Zhang*, Xianwen Yang*, Haifeng Chen*. Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi.Frontiers in Microbiology. 2021,11: 636948

13. Xiansheng Ye, Wenjing Tian, Mi Zhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways. Bioorg. Med. Chem. Lett.2021, 38: 127859

14. Jie Feng#, Danyang Zhao#, Qiannan Xu, Xiangzhong Liu, Mi Zhou, Xiansheng Ye, Ting Lin, Guanghui Wang, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities. Natural Product Research. 2020, doi.org/10.1080/14786419.2020.1855166

15. Xiansheng Ye, Wenjing Tian, Guanghui Wang, Xian Zhang, Mi Zhou, Dequan Zeng, Xiangzhong Liu, Xinsheng Yao*, Yunwu Zhang*, and Haifeng Chen*.Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities. Journal of Agricultural and Food Chemistry. 2020, 68: 4196-4204

16. Qiannan Xu, Dan Zhu, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum. Natural Product Research, 2020, doi.org/10.1080/14786419.2020.1739044

17. Xiaoyao Wang, Xiansheng Ye, Shuo Gao, Jinji Liu, Wenjing Tian, Guanghui Wang, Haifeng Chen*, Ting Lin*. Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4. Fitoterapia,2020, 147, doi.org/10.1016/j.fitote.2020.104766

18. Daren Qiu, Mi Zhou, Xiangzhong Liu, Junjie Chen, Guanghui Wang, Ting Lin, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα. Bioorganic Chemistry, 2020,170: doi.org/10.1016/j.bioorg.2020.104578

19. Daren Qiu, Mi Zhou, Junjie Chen, Guanghui Wang, Ting Lin, Yujie Huang, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα. Phytochemistry, 2020, 170:doi.org/10.1016/j.phytochem.2019.112216

20. Mi Zhou, Borong Peng, Wenjing Tian, Juihsin Su, Guanghui Wang, Ting Lin, Dequan Zeng, Jyhhorng Sheu*, and Haifeng Chen*. 2-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77. Marine Drugs, 2020, 18: 375-388

21. Shuiyuan Yang, Wenjing Tian, Zhenrui Pan, Ting Lin, Guanghui Wang, Qiang Zhou, Yuhua Xue*, and Haifeng Chen*. POLYPHENOLS FROM Polygonum cuspidatum REACTIVATE LATENT HIV. Chemistry of Natural Compounds, 2020, 56(2): 318-322

22. Shuo Gao, Wenjing Tian, Zujian Liao, Guangjui Wang, Dequan Zeng, Xiangzhong Liu, Xiaoyao Wang, Hu Zhou, Haifeng Chen*, and Ting Lin*. Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii. Chemistry &Biodiversity,2020, (17)9, DOI: 10.1002/cbdv.202000424

23. Shengmei Zhang, Feirong Huang, Wenjin Tian, Jiashuang Lai, Lixia Qian, Wanjin Hong*, Haifeng Chen*, Liang-cheng Li*. Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1.Biochemical Pharmacology, 2020, (174), doi.org/10.1016/j.bcp.2019.113785

24. ChunLan Xie, Duo Zhang, Jinmei Xia, Chaochao Hu, Ting Lin, Yukun Lin, Guanghui Wang, Wenjing Tian, Zengpeng Li, Xiaokun Zhang, Xianwen Yang*, Haifeng Chen*. Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)- Pathway. Marine Drugs, 2019, 17,178-191

25. Daren Qiu, Mi Zhou, Ting Lin, Junjie Chen, Guanghui Wang, Yujie Huang, Xin Jiang, Wenjing Tian*, Haifeng Chen*. Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage. Journal of Natural Products, 2019, 82(5):1072-1080

26. Xiangzhong Liu, Wenjing Tian, Guanghui Wang, Qiannan Xu, Mi Zhou, Shuo Gao, Daren Qiu, Xin Jiang, Cuiling Sun, Rong Ding, Ting Lin*, Haifeng Chen*.Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina. Phytochemistry, 2019, 158: 67-76

Tel: +86-592-2187225

Fax: +86-592-2187225

Email:  haifeng@xmu.edu.cn