Wang  Tuanlao, Ph.D

Professor

Experience:

Dr. Wang received his bachelor degree from Nanjing Agricultural  University, his master degree and Ph.D. degree from Xiamen University in China.  In 1999, He went to Singapore joined the Institute of Molecular and Cell Biology  as a Research Fellow, In 2007, he was recruited toXiamen University as Professor of the school  of pharmaceutical sciences.

Research :

The membrane trafficking (or protein transport) pathway includes  exocytosis and endocytosis. The proteins synthesized on ribosomes associated  with the endoplasmic reticulum (ER) are transported via vesicle from ER to the  Golgi apparatus, then secreted out of the cell, or transported from the Golgi  apparatus to the endosome and lysosome for degradation. At the same time, cells  take-up nutrients via endocytosis, by which materials are internalized from cell  surface and transported to the endosome and lysosome or the Golgi apparatus. The  receptor-mediated endocytosis is also closely related to cellular signal  transduction, and this process regulates cell growth, proliferation, and death.  Many pathogens like viruses, bacteria invade cell also via endocytic or  phagocytic pathways.

Our lab’s researches focus on investigating the cellular and  molecular mechanisms governing membrane traffic in the secretory and endocytic  pathways and the roles of membrane trafficking in diseases, exploiting the novel  drug targets and biomarkers for diseases from membrane traffic  machineries.

Selected  Publications (last 5 years):

1. Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B. Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy. Diabetes. 2023 May 1;72(5):611-626.

2. Xu L, Zhou Y, Wang G, Bo L, Jin B, Dai L, Lu Q, Cai X, Hu L, Liu L, Wu Y, Chang X, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Liu L, Shi M, Wang T, Guo B. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation. Cell Death Dis. 2023 Feb 27;14(2):166. doi: 10.1038/s41419-023-05685-4.

3. Yap CC, Digilio L, McMahon LP, Wang T, Winckler B. Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation. J Neurosci. 2022 Jun 1;42(22):4415-4434.

4. Liu H, Zhou Y, Qiu H, Zhuang R, Han Y, Liu X, Qiu X, Wang Z, Xu L, Tan R, Hong W, Wang T. Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src. Cell Death Dis. 2021 Mar 17;12(4):284. doi: 10.1038/s41419-021-03561-7.

5.       Zhou Y, Liu Z, Zhang S, Zhuang R, Liu H, Liu X, Qiu X, Zhang M, Zheng Y, Li L, Hong W, Wang T.RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin. Diabetes. 2020 Jan;69(1):67-82.

6.       Sun L, Xu X, Chen Y, Zhou Y, Tan R, Qiu H, Jin L, Zhang W, Fan R, Hong W, Wang T. Rab34 regulates adhesion, migration, and invasion of breast cancer cells.Oncogene. 2018 Jul;37(27):3698-3714

Tel: +86-592-218-7228

Fax: +86-592-218-1879

Email: xmuibrwtl@xmu.edu.cn