• 简介目录
 
张凌娟教授

发布者:张欧扬发布时间:2018-07-09浏览次数:10

 PI:张凌娟 博士、教授、博士生导师

中组部“青年千人计划”、“闽江学者”特聘教授、厦门大学“南强青年拔尖A类人才”


个人简介

张凌娟博士在美国有近15年分子生物学和基础医学领域的学习研究经历,及近10年皮肤医学专项领域的研究经验。特别是近年在皮肤天然免疫机制及调控领域开展了一系列独创性的研究工作,发现脂肪前体细胞 (Preadipocytes/Adipocytes) 有免疫抑菌功能,可通过大量释放多肽抗生素来抵御细菌感染,这种抗菌多肽还在表皮角化细胞 (Keratinocytes) 里参与银屑病皮肤炎症的调控, 上述研究成果以第一作者身份在ScienceImmunity Current Biology等国际顶级学术期刊上,多次受邀在国际学术会议上做学术报告。2011年起,为Journal of Investigative DermatologyJournal of Biological ChemistryOncotarget等杂志担任专业审稿人审阅了近100篇研究论文。 2007年至2011年,担任American Association of Cancer Research (AACR) 专业协会成员; 2011起担任Society of Investigative Dermatology (SID) 专业协会成员。 在UCSD期间以PI身份主持美国国立卫生研究院(NIH) R01研究课题(2百万美金/5年)。2018年加入厦门大学药学院,继续在皮肤天然免疫及皮肤炎症调控领域开展科研工作。


教育背景与科研经历

2018-至今教授,厦门大学药学院

2014-2018项目科学家,美国加州大学圣地亚哥分校,皮肤医学系,医学院

2011-2014博士后,美国加州大学圣地亚哥分校,皮肤医学系,医学院

2009-2011博士后,美国俄勒冈州立大学,药学院

2009博士美国俄勒冈州立大学,专业:药理学

2003学士北京理工大学,专业:生物工程


代表性论文:

1. Ling-juan Zhang. Keratin ("Biochemistry" Book Series). In press, 2018. ISBN 978-953-51-6296-4. Book chapter title: Keratins in Skin Epidermal Development and Diseases.

2. Toshiya Takahashi, Nikhil Nitin Kulkarni, Ernest Y Lee, Ling-juan Zhang, Gerard C.L. Wong, Richard L. Gallo. Scientific Report, 2018, 8, Article number: 4032 (2018). Title: Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors.

3. Nikhil N Kulkarni, Christopher A Adase, Ling-juan Zhang, Andrew W Borkowski, Fengwu Li, James A Sanford, Daniel J Coleman, Carlos Aguilera, Arup K Indra, Richard L Gallo. Journal of Investigative Dermatology, Volume 137, Issue 11, November 2017, Pages 2417-2426. Title:Interleukin-1 receptor knockout mice develop epidermal cysts and show an altered innate immune response following exposure to ultraviolet B radiation

4. Fengwu Li, Chris Adase and Ling-juan Zhang (contact author). Journal of Visualized Experiments, e5602, 2017. Title: Isolation and culture of primary mouse keratinocytes from neonatal and adult mouse skin.

5. Emi Sato, Lingjuan Zhang, Robert Dorschner, Chris Adase, Biswa Choudhury, and Richard Gallo. Journal of Investigative Dermatology, 2017 Apr 25. pii: S0022-202X(17)31424-0.,2017. Title:Activation of parathyroid hormone 2 receptor induces decorin expression and promotes wound repair

6. Yanhan Wang, Ling-juan Zhang, Jinghua Yu, Stephen Huang, Zhenping Wang, Kimberly Ann Chun, Tammy Ling Lee, Richard L. Gallo and Chun-Ming Huang. Journal of Investigative Dermatology, 2017 Jan;137(1):46-56. Title:A Co-drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation

7. James A. Sanford, Ling-juan Zhang, Michael R. Williams, Jon A. Gangoiti, Chun-Ming Huang and Richard L. Gallo. Science Immunology, 28 Oct 2016: Vol. 1, Issue 4, eaah4609. Title: Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands.

8. Ling-juan Zhang, George L. Sen, Nicole L. Ward, Andrew Johnston, Kimberly Chun, Yifang Chen, Christopher Adase, James A. Sanford, Nina Gao, Melanie Chensee, Emi Sato, Yi Fritz, Jaymie Baliwag, Michael R. Williams, Tissa Hata, Richard L. Gallo. Immunity, 2016 Jul 19;45(1):119-30. Title: Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury.

9. Christopher A. Adase, Andrew Borkowski, Ling-juan Zhang, Michael Williams, James A Sanford and Richard L. Gallo. (2016)Journal of Biological Chemistry, 2016 May 27;291(22):11635-46. Title: Non-coding double-stranded RNA and LL-37 induce growth factor expression from keratinocytes and endothelial cells

10. Emi Sato, Jun Muto, Ling-juan Zhang, Chris Adase, James A. Sanford, Toshi Takahashi, Teru Nakatsuji, Robert A. Lee, and Richard L Gallo (2016). Journal of Investigative Dermatology, 74(4):772-4,Title: The parathyroid hormone second receptor PTH2R, and its ligand tuberoinfundibular peptide of 39 residues TIP39, regulate intracellular calcium and influence keratinocyte differentiation.

11. Ling-juan Zhang and Richard Gallo, (2016)Current Biology, Jan 11;26(1):R14-9. Title: Antimicrobial peptides (Review article).

12. Bouslimani A, Porto C, Rath CM, Berg-Lyon D, Ackermann G, Nakatsuji T, Zhang LJ, Borkowski AW, Meehan MJ, Dorrestein K, Gallo RL, Bandeira N, Knight R, Alexandrov T, Dorrestein PC. (2015) Proc Natl Acad Sci U S A, Apr 28;112(17):E2120-9.,Title:Molecular cartography of the human skin surface in 3D.

13. Ling-juan Zhang, Christian F. Guerrero-Juarez, Tissa Hata, Sagar P. Bapat, Raul Ramos, Maksim V. Plikus, Richard L. Gallo. (2015) Science, 347(6217):67-71, Title:Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

14. Ling-juan Zhang, Zhixing Wang (co-first author), Gunjan Guha, Shan Li, Kateryna Kyrylkova, Chrissa Kioussi, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra. (2012) Plos One, 7(12): e51262. Title: Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-like Skin Inflammatory Responses in Adult Mice

15. Zhang LJ, Bhattacharya S, Leid M, Ganguli-Indra G, Indra AK. (2012)Journal of Cell Science, 125, 5733-5744;Title: Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling.

16. Zhang LJ, Vogel WK, Liu X, Topark-Ngarm A, Arbogast BL, Maier CS, Filtz TM, Leid M. (2012) Journal of Biological Chemistry, 287(32):26971-88; Title: Coordinated regulation of transcription factor Bcl11b activity in thymocytes by the mitogen-activated protein kinase (MAPK) pathways and protein sumoylation.

17. Zhang, L. J., Liu, X., Gafken, P. R., Kioussi, C., and Leid, M. (2009) Journal of Biological Chemistry, 284, 6156-6168; Title: A Chicken Ovalbumin Upstream Promoter Transcription Factor I (COUP-TFI) Complex Represses Expression of the Gene Encoding Tumor Necrosis Factor -induced Protein 8 (TNFAIP8); Note: This is paper was selected by JBC as the paper of the week, which is about top 1% of all 6600 papers published each year in JBC.

18. Kastner P, Chan S, Vogel WK, Zhang LJ, Topark-Ngarm A, Golonzhka O, Jost B, Le Gras S, Gross MK, Leid M.(2010) Eur J Immunol., Title: Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes


招聘:本实验室诚招副教授,助理教授,博士后,博士及硕士研究生。


联系方式:

地址:厦门市翔安区翔安南路厦门大学翔安校区药学院321

电话: 0592-2182453   

邮箱: lingjuan.zhang@xmu.edu.cn



 
 
Copyright©2011 http://pharm.xmu.edu.cn 版权所有:厦门大学药学院
地 址:厦门市翔安区翔安南路 邮编:361102 电 话:0592-2182453 2181852
D200695
[后台管理]