Dr. Wolfgang Dubiel

发布者:张欧扬发布时间:2017-05-09浏览次数:685

Dr. Wolfgang Dubiel

        Dubiel 教授于1982年在德国柏林洪堡大学生物化学研究所获得博士学位。在柏林洪堡大学和美国盐湖城州犹他大学生物化学系做过博士后工作后,他在1993年回到了洪堡大学的生物化学研究所担任讲师。在1999年,Dubiel教授被柏林夏里特医学院委任为分子生物学部主任,主管常规内脏,血管,胸外科部门。2016年,Dubiel教授应邀成为一名在厦门大学药学院的客座教授,所属Dieter A. Wolf教授的实验室

Dr. Dubiel obtained his Ph.D. at the Institute of Biochemistry, Humboldt University Berlin in 1982. After postdoctoral work at the Humboldt University Berlin and at the Department of Biochemistry, University of Utah, Salt Lake City, USA, he returned to the Institute of Biochemistry, Humboldt University Berlin as a lecturer in 1993. In 1999, Dr. Dubielobtained an appointment as a Professor and became the Head of the Division of Molecular Biology, Department of General, Visceral, Vascular and Thoracic Surgery, Charité – Universitätsmedizin Berlin. In 2016, Dr. Dubiel was invited as a Visiting Professor at the School of Pharmaceutical Sciences, Xiamen University, inDr. Dieter A. Wolf’s laboratory.  

        Dubiel教授是一名在细胞内蛋白质降解的泛素蛋白酶体系统领域的领先专家。他最重大的成就是COP9 信号小体(CSN)复合物的发现,它是cullin-RING泛素连接酶的调节器。自2000年以来,他的研究主要着重于CSN在人体细胞中的结构和功能特征,以及其作为肿瘤靶点药物的效用。最近的成就是CSN作为一种脂肪细胞分化的主要调节器的鉴定,关于脂肪细胞的分化。CSN参与重新建模的CRL网络在脂肪细胞转为分化模式。这使得CSN成为一个为治疗肥胖和其他代谢性疾病的有吸引力的目标。

Dr. Dubiel is a leading expert in the field of intracellular protein degradation by the ubiquitin proteasome system. Among his most important achievements is the discovery of the COP9 signalosome complex (CSN), a regulator of cullin-RING ubiquitin ligases (CRLs).Since 2000, his research is focused on the structural and functional characterization of the CSN in human cells as well as its utility as cancer drug target. A very recent achievement was the identification of the CSN as a master regulator of adipogenesis, the differentiation of fat cells (adipocytes). The CSN is involved in the re-modeling of the CRL network in adipocytes to switch to the differentiation mode. This makes the CSN an attractive target for the treatment of obesity and other metabolic diseases.

    在厦门大学Wolf教授的实验室,Dubiel教授将着重于研究CSN的作用和CSN变种在肿瘤细胞和脂肪细胞的分化过程。在和Wolf教授的合作中,他将筛选一个新的库,主要是关于中国南海大量未经开发的自然资源,这个项目正在由药学院张教授的小组开发。通过使用这个库,他希望能确定脂肪细胞通路的新型调制器,这样可以针对CSN在代谢疾病方面提供概念证明。

At Xiamen University, in Dr. Wolf’s lab, Dr. Dubiel will focus on the role of the CSN and of CSN variants in tumor cells and during adipogenesis. In collaboration with Dr. Wolf, he will screena new library of largely unexplored natural product resources of the South China Sea presently being developed in Dr. Zhang’s group. Using this library, he expects to identify novel modulators of adipogenic pathways that could provide proof-of-concept for targeting the CSN in metabolic disease.

  

Huang X, Ordemann J, Pratschke J, Dubiel W. (2016) Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation. FEBS Open Bio. 6, 1102-1112

  

Gummlich L, Kähne T, Naumann M, Kilic E, Jung K, Dubiel W. (2016) New Insights Into the Mechanism of COP9 Signalosome-Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological Cancers.Int Rev Cell Mol Biol. 323, 181-229

  

  

Dubiel D, Ordemann J, Pratschke J, Dubiel W, Naumann M. (2015) CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis.Int J Biochem Cell Biol. 66, 95-100

  

Huang X, Ordemann J, Müller JM, Dubiel W. (2012)The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis.Biol Open. 1, 705-710

  

Leppert U, Henke W, Huang X, Müller JM, Dubiel W. (2011) Post-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway.J Mol Biol. 409, 710-721

  

Hetfeld BK, Helfrich A, Kapelari B, Scheel H, Hofmann K, Guterman A, Glickman M, Schade R, Kloetzel PM, Dubiel W. (2005)The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.Curr Biol. 15, 1217-1221

  

Zhou C, Wee S, Rhee E, Naumann M, Dubiel W, Wolf DA. (2003) Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.Mol Cell. 11, 927-938

  

Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, Dubiel W. (2003) Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.EMBO J. 22, 1302-1312