Xiang Gao, Xiamen University

发布者:张欧扬发布时间:2016-03-16浏览次数:339

Dr. Gao, Xiang

Associate Professor

  

Educations and Scientific Experience:

2013.08-Present Associate Professor, School of Pharmaceutical Sciences, Xiamen University

2011.02-2012.08 Postdoc. Fellow, Department of Chemistry,Hong Kong Baptist University

2007.09-2010.08 Ph.D, Department of Chemistry,Xiamen University 2004.09-2007.07 Master, Department of Chemistry, Xiamen University

2000.09-2004.07 B.Sc., Department of Chemistry, Southwest University

  

Research Interests:

Fundamentals and applications of mass spectrometry

Development of novel stable isotope labeling methods for quantitative proteomics and metabolomics

Protein-protein interactions of HIV-1 gene transcription elongation

Organic phosphorus chemistry: Prebiotic chemistry of P-N bonds

  

Publications:

1.Yuan, Hang; Ying, Jianxi; Deng, Peiran; Chen, Peng; Shi, Jinwen; Liu, Yan; Gao, Xiang; Zhao, Yufen. Specific interactions of leucine with disaccharides by electrospray ionization mass spectrometry: application to rapid differentiation of disaccharide isomers in combination with statistical analysis. Analyst, 2015, 140(23), 7965-7973.

2.Fang, Mei-Juan; Zhang, He; Liao, Chao; Qiu, Ying-Kun; Fang, Hua; Zheng, Zhen-Yu; Gao, Xiang; Zhao, Yu-Fen; Wu, Zhen. Using positive-ion electrospray ionization mass spectrometry and H/D exchange study phosphoryl group transfer reactions involved in amino acid ester isopropyl phosphoramidates of Brefeldin A. AnalyticaChimicaActa, 2015, 853, 391-401.

3.Gao, Wei-wei; Xiao, Rong-quan; Peng, Bing-ling; Xu, Huan-teng; Shen, Hai-feng; Huang, Ming-feng; Shi, Tao-tao; Yi, Jia; Zhang, Wen-juan; Wu, Xiao-nan; Gao, Xiang; Lin, Xiang-zhi, Dorrestein, Pieter C.; Rosenfeld, Michael G.; Liu, Wen.Arginine methylation of HSP70 regulates retinoid acid-mediated RAR beta 2 gene activation. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(26), E3327-E3336.

4.Hang Yuan; Yile Wu; Wu Liu; Yan Liu; Xiang Gao; Jinming Lin; Yufen Zhao. Mass spectrometry-based method to investigate the natural selectivity of sucrose as the sugar transport form for plants. Carbohydrate Research, 2015, 407, 5-9.

5.Chen, Xiaowu; Gao, Dan; Liu, Feng; Gao, Xiang; Wang, Shujuan; Zhao, Yufen; Liu, Hongxia; Jiang, Yuyang. A novel quantification method for analysis of twenty natural amino acids in human serum based on N-phosphorylation labeling using reversed-phase liquid chromatography-tandem mass spectrometry. AnalyticaChimicaActa, 2014, 836(1), 61-71.

6.Gao, Yuzhen; Xu, Jian; He, Yaohui; Tang, Guo; Lin, Zhiwei; Liu, Hongxia; Gao, Xiang; Zhao, Yufen. Cleavage of phosphorus-carbon (P-C) bonds of alpha-amino phosphonates with intramolecular hydrogen migration in the gas phase using electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2014, 28(18), 1964-1970.

7.Liu, Liu; Wu, Yile; Wang, Tao; Gao, Xiang; Zhu, Jun; Zhao, Yufen. Mechanism, Reactivity, and Selectivity in Rh(III)-Catalyzed Phosphoryl-Directed Oxidative C-H Activation/Cyclization: A DFT Study.Journal of Organic Chemistry, 2014, 79(11), 5074-5081.

8.Wu, Hanzhi; Song, Wenjun; Gao, Xiang; Liu, Ning; Wang, Pui; Chen, Honglin; Cai, Zongwei. Proteomics study of N-acetylcysteine response in H1N1-infected cells by using mass spectrometry. Rapid Communications in Mass Spectrometry, 2014, 28(7), 741-749

9.Li, Yucui; Su, Ziren; Lin, Shuhai; Li, Chuwen; Zhao, Ya; Gao, Xiang; Lai, Yongquan; Wu, Xiaoli; Wu, Hanzhi; Cai, Zongwei; Lai, Xiaoping. Characterisation of the Metabolism of PogostoneIn Vitro and In Vivo Using Liquid Chromatography with Mass Spectrometry. Phytochemical Analysis, 2014, 25(2), 97-105.

10.Gao, X.; Bi, X.; Wei, J. T.; Peng, Z. M.; Liu, H. X.; Jiang, Y. Y.; Wei, W.; Cai, Z. W. N-phosphorylation labeling for analysis of twenty natural amino acids and small peptides by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analyst 2013, 138, 2632-2639.

11.Gao, X.; Wu, H. Z.; Lee, K. C.; Liu, H. X.; Zhao, Y. F.; Cai, Z. W.; Jiang, Y. Y. Stable isotope N-phosphorylation labeling for peptide de novo sequencing and protein quantification based on organic phosphorus chemistry. Anal. Chem. 2012, 84, 10236-10244.

12.Gao, X.; Tang, Z.; Lu, M. H.; Liu, H. X.; Jiang, Y. Y.; Zhao, Y. F.; Cai, Z. W. Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry. Chem. Commun. 2012, 48, 10198-10200.

13.Gao, X.; Hu, X. M.; Zhu, J.; Zeng, Z. P.; Han, D. X.; Tang, G.; Huang, X. T.; Xu, P. X.; Zhao, Y. F. An isotope (18O, 15N, and 2H) technique to investigate the metal ion interactions between the phosphoryl group and amino acid side chains by electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22: 689-702.

14.Gao, X.; Deng, H. G.; Xu, P. X.; Liu, Y.; Tang G.; Zhao, Y. F. Inter-molecular phosphoryl transfer of N-phosphoryl amino acids. Eur. J. Org. Chem. 2011, 17: 3220-3228.

15.Gao, X.; Chen, W. Z.; Zhu, G. T.; Yi, R. Z.; Wu, Z.; Xu, P. X.; Zhao, Y. F. Fast separation of antiviral nucleoside phosphoramidate and H-phosphonate diastereoisomers by reversed-phase liquid chromatography. J. Chromatogr. A 2011, 1218: 1416-1422.

16.Gao, X.; Zhu, G. T.; Zeng, Z. P.; Chen, W. Z.; Lin, Z. W.; Liu, Y.; Xu, P. X.; Zhao, Y. F. A novel methyl migration to phosphoryl group with the formation of cyclic aminoacylphosphoramidate in electrospray ionization tandem mass spectra of amino acid ester phosphoramidates of antiviral nucleoside. Rapid Commun. Mass Spectrom. 2011, 25: 1061-1069.

17.Gao, X.; Zeng, Z. P.; Xu, P. X.; Tang, G.; Liu, Y.; Zhao, Y. F. Comparison of the isomeric alpha-amino acyl adenylates and amino acid phosphoramidates of adenosine by electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25, 291-300.

18.Gao, X.; Ni, F.; Bao, J.; Liu, Y.; Xu, P. X.; Zhao, Y. F. Formation of cyclic acylphosphoramidates in mass spectra of N-monoalkyloxyphosphoryl amino acids using electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 2010, 45: 779-787.

19.Gao, X.; Zhuang, R. Q.; Guo, J. N.; Bao, J.; Fang, M. J.; Liu, Y.; Xu, P. X.; Zhao, Y. F. Isolation and purification of macrocyclic components from penicillium fermentation broth by high-speed counter-current chromatography. J. Sep. Sci. 2010, 33: 277-284.

20.Gao, X.; Xu, P. X.; Liu, Y.; Li, G.; Zhao, Y. F. Stable-isotope labeling technique to investigate the chemical structures and reaction mechanisms using ESI-MS. Chin. J. Anal. Lab. 2010, 29 (S): 1-3.

21.Gao, X.; Liu, Y.; Xu, P. X.; Cai, Y. M.; Zhao, Y. F. alpha-Amino acid behaves differently from beta- or gamma-amino acids as treated by trimetaphosphate. Amino Acids 2008, 34: 47-53.

  

  

Contacts:

Room 435(Office), School of Pharmaceutical Sciences, Xiamen University, Xiang’an South Road, Xiamen, China

Post code: 361102

Phone: 0592-2881178

E-mail: xgao@xmu.edu.cn