• 简介目录
 
吴云龙副教授

发布者:张欧扬发布时间:2016-03-14浏览次数:2832


吴云龙博士,副教授




个人简介:

吴云龙,男。2005年取得中国科学技术大学材料化学专业理学学士学位,2011年获新加坡国立大学生物工程博士学位。2010-2012年在南洋理工大学材料科学与工程学院从事博士后工作。2012年应聘为厦门大学药学院助理教授,2014年聘为厦门大学药学院副教授。主要研究方向:超分子自组装、基于环糊精的药物或基因载体设计、细胞牵引力显微镜。主要研究成果包括利用环糊精的分子识别操控其自组装为有序超分子结构,并探索超分子结构作为药物载体的优势。同时还对于细胞牵引力显微镜的开发用于观测细胞物理性能的实时动态变化过程有着浓厚的兴趣。近年,主持了国家自然科学基金青年基金项目(21303145)、福建省自然科学基金项目(2014J01063)、中央专项基本科研项目(2013121037)、院长基金项目;作为项目共同负责人或技术骨干参与科技部国家国际科技合作专项(第十期中国新加坡联合研究计划JRP102014DFG32660)、国家自然科学基金(3134002931471273)以及南方海洋研究中心专项(14GYY023NF23)等多项科研项目。


教育经历:

2001.09-2005.07:中国科学技术大学,材料化学学士;

2005.08-2011.06:新加坡国立大学,生物工程博士;

2009.09-2010.03:新加坡国立大学,生物工程系研究工程师;

2011.08:德国海德堡大学,合作研究者;

2010.05-2012.05:新加坡南洋理工大学,材料科学与工程学院博士后。


研究兴趣:

基于环糊精的新型高效药物及基因载体的设计与合成

基于环糊精的超分子自组装从而达到多功能药物载体的设计与合成

牵引力显微镜的设计及其在新兴生物力学领域特别是细胞力谱描绘上的应用


代表性论文:

2017

1. Cheng, H.; Wu, Z.; Wu, C.; Wang, X.; Liow, S. S.;Li, Z.;Wu, Y.-L.* ²Overcoming STC2 Mediated Drug Resistance Through Drug and Gene Co-delivery by PHB-PDMAEMA Cationic Polyester in Liver Cancer Cells.²Materials Science and Engineering: C, 2017, DOI: 10.1016/j.msec.2017.08.075. (SCI impact factor: 4.164)

2. Fan, X.; Wang, X.; Cao, M.; Wang, C.; Hu, Z.; Wu, Y.-L.*;Li, Z.*; Loh, X. J.²²Y²-Shape Armed Amphiphilic Star-like Copolymer: Design, Synthesis and Dual-Responsive Unimolecular Micelle Formation for Controlled Drug Delivery.²Polymer Chemistry, 2017, 8(36): 5611-5620. (SCI impact factor: 5.375)

3. Wu, Y.-L.; Engl, W.; Hu, B.; Cai, P.; Leow, W. R.; Tan, N. S.; Lim, C. T.; Chen, X.* Nanomechanically Visualizing Drug-Cell Interaction at the Early Stage of Chemotherapy.ACS Nano, 2017, 11(7): 6996-7005. (SCI impact factor: 13.942)

4. Cai, P.; Leow, W. R.; Wang, X.; Wu, Y.-L.*; Chen, X.* ²Programmable Nano-Bio Interfaces for Functional Biointegrated Devices.²Advanced Materials, 2017, 29(26): 1605529. [Featured as Inside Back Cover][Highlighted by Materials Views China: http://www.materialsviewschina.com/2017/05/24998/] (SCI impact factor: 19.791)

5. Liu, X.; Chen, X.; Chua, M. X.; Li, Z.; Loh, X. J.; Wu, Y.-L.*²Injectable Supramolecular Hydrogels as Delivery Agents of Bcl-2 Conversion Gene for the Effective Shrinkage of Therapeutic Resistance Tumors.²Advanced Healthcare Materials, 2017, 6(11): 1700159. [Featured as Front Cover] [Highlighted by Advanced ScienceNews: http://www.advancedsciencenews.com/cover-art-featuring-cancer-therapy-angiogenesis-tissue-engineering/] [Highlighted by Materials Views China: http://www.materialsviewschina.com/2017/07/25828/] (SCI impact factor: 5.110)

6. Wang, X.;Liow, S. S.; Wu, Q.; Li, C.; Owh, C.; Li, Z.; Loh, X. J.; Wu, Y.-L.* ²Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.²Macromolecular Bioscience, 2017, 17, DOI: 10.1002/mabi.201700186. (SCI impact factor: 3.238)

7. Li, Z.; Liu, X.; Chen, X.; Chua, M. X.; Wu, Y.-L.*²Targeted Delivery of Bcl-2 Conversion Gene by MPEG-PCL-PEI-FA Cationic Copolymer to Combat Therapeutic Resistant Cancer.²Materials Science and Engineering: C, 2017, 76: 66-72. (SCI impact factor: 4.164)

8. Liow, S. S.; Dou, Q.; Kai, D.; Sugiarto S.; Yu, C. Y. Y.; Kwok, R. T. K.; Chen, X.; Wu, Y.-L.*; Ong, S. T.; Kizhakeyil, A.; Verma N. K.; Tang, B. Z.; Loh, X. J.* ²Long-term Real-time in vivo Drug Release Monitoring with AIE Thermogelling Polymer.²Small, 2017, 13(7): 1603404. [Featured as Back Cover] (SCI impact factor: 8.643)

9. Zheng, C.; Gao, H.; Yang, D.-P.; Liu, M.; Cheng, H.; Wu, Y.-L.*; Loh, X. J. ²PCL-based Thermo-gelling Polymers for In Vivo Delivery of Chemotherapeutics to Tumors.²Materials Science and Engineering: C, 2017, 74: 110-116. (SCI impact factor: 4.164)

10. Wang, P.; Zeng, W.; Liu, J.;Wu, Y.-L.; Ma, Y.; Zeng, Z.; Pang, J.-y.; Zhang, X.-k.; Yan, X.; Wong, A.; Zeng, J.-Z.²TRC4, an Improved Triptolide Derivative, Specifically Targets to Truncated Form of Retinoid X Receptor-alpha in Cancer Cells.²Biochemical Pharmacology, 2017, 124: 19-28. (SCI impact factor: 4.581)

11. Li, J.-F.; Yan, X.; Wu, Y.-L.; Fang, M.-J.; Wu, Z.; Qiu, Y.-K.*²Comprehensive Two-dimensional Normal-phase Liquid Chromatography × Reversed-phase Liquid Chromatography for Analysis of Toad Skin.²AnalyticaChimicaActa, 2017, 962: 114-120. (SCI impact factor: 4.950)

12. Zeng W.; Zhang, C.; Cheng, H.; Wu, Y.-L.; Liu, J.; Chen, Z.; Huang, J. G.; Ericksen, R. E.; Chen, L.; Zhang, H.; Wong, A. S.; Zhang, X.-k.; Han, W.; Zeng, J.-Z. ²Targeting to the Non-genomic Activity of Retinoic Acid Receptor-Gamma by Acacetin in Hepatocellular Carcinoma.²Scientific Reports, 2017, 7: 348. (SCI impact factor: 4.259).

13. Hu, B.; Leow, W. R.; Amini, S.;Nai, B.; Zhang, X.; Liu, Z.; Cai, P.; Li, Z.; Wu, Y.-L.; Miserez, A.; Lim, C. T.; Chen, X.*²Orientational Coupling Locally Orchestrates a Cell Migration Pattern for Re-Epithelialization.²Advanced Materials, 2017, 29(29): 1700145. (SCI impact factor: 19.791)

14. Wee, C. Y.; Liow, S.S.; Li, Z.; Wu, Y.-L.; Loh, X. J.²New Poly[(R)-3-hydroxybutyrate-co-4-hydroxybutyrate] (P3HB4HB)-Based Thermogels.²Macromolecular Chemistry and Physics, 2017, 218(17): 1700196. (SCI impact factor: 2.500)

15. Wang, Y.-Q.; Tang, X.; Li, J.-F.; Wu, Y.-L.; Sun, Y.-Y.; Fang, M.-J.; Wu, Z.; Wang, X.-M.; Qiu, Y.-K.²Development of an On-Line Mixed-Mode Gel Liquid Chromatography × Reversed Phase Liquid Chromatography Method for Separation of Water Extract from FlosCarthami.²Journal of Chromatography A, 2017, 1519: 145-151. (SCI impact factor: 3.981)

2016

16. Chen, X.; Qiu, Y.-K.;Owh, C.; Loh, X. J.; Wu, Y.-L.*²Supramolecular CyclodextrinNanocarriers for Chemo- and Gene Therapy towards the Effective Treatment of Drug Resistant Cancers.²Nanoscale, 2016, 8(45): 18876-18881. (SCI impact factor: 7.367)

17. Wu, Y.-L.*; Wang, H.; Qiu, Y.-K.; Liow, S. S; Li, Z.; Loh, X. J.²PHB-based Gels as Delivery Agents of Chemotherapeutics for the Effective Shrinkage of Tumors.²AdvancedHealthcare Materials, 2016, 5(20): 2679-2685. [Highlighted by http://www.advancedsciencenews.com/injectable-hydrogels-for-precise-chemotherapy/] (SCI impact factor: 5.110)

18. Wu, Y.-L.*; Wang, H.; Qiu, Y.-K.; Loh, X. J.²PLA-based Thermogel for the Sustained Delivery of Chemotherapeutics in a Mouse Model of Hepatocellular Carcinoma.²RSC Advances, 2016, 6(50): 44506-44513. (SCI impact factor: 3.108)

19. Li, J.-F.; Fang, H.; Yan, X.; Chang, F.-R.; Wu, Z.; Wu, Y.-L.*; Qiu, Y.-K.*²On-line Comprehensive Two-dimensional Normal-phase Liquid Chromatography× Reversed-phase Liquid Chromatography for Preparative Isolation of Toad Venom.²Journal of Chromatography A, 2016, 14556(22): 169-175. (SCI impact factor: 3.981)

20. Lin, N.; Chen, X.; Yan, S.; Wang, H.; Lu, Z.; Xia, X.; Liang, M.;Wu, Y.-L.*; Zheng, L.*; Cao Q.*; Ding, Z.²An Aggregation-Induced Emission Based pH-sensitive FluorescentProbe for Intracellular Acidity Sensing.²RSC Advances, 2016, 6(30):25416-25419. (SCI impact factor: 3.108)

21. Wu, Y.-L.; Chen, X.; Wang, W.; Loh, X. J.²Engineering BioresponsiveHydrogels towards Healthcare Applications.²Macromolecular Chemistry and Physics, 2016, 217(2): 175-188. [Featured in Front Cover] (SCI impact factor: 2.500)

22. Cai, P.; Layani, M.; Leow, W. R.; Amini, S.; Liu, Z.; Qi, D.; Hu, B.; Wu, Y.-L.; Miserez, A.; Magdassi, S.; Chen, X.* ²Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration.²Advanced Materials, 2016, 28(16): 3102-3110. (SCI impact factor: 19.791)

23. Yan, X.; Wang, L.-J.; Wu, Z.;Wu, Y.-L.; Liu, X.-X.; Chang, F.-R.; Fang, M.-J.; Qiu, Y.-K.²New On-Line Separation Workflow of Microbial Metabolites via Hyphenation of Analytical and Preparative Comprehensive Two-Dimensional Liquid Chromatography.²Journal of Chromatography B, 2016, 1033-1034: 1-8. (SCI impact factor: 2.603)

Before 2015

24. Tay, C. Y.; Wu, Y.-L.; Cai, P.; Tan, N. S.; Venkatraman, S. S.; Chen, X.; Tan, L. P.²Bio-inspired MicropatternedHydrogel to Direct and Deconstruct Hierarchical Processing of Geometry-force Signals by Human Mesenchymal Stem Cells during Smooth Muscle Cell Differentiation.²NPG Asia Materials, 2015, 7(7): e199. (SCI impact factor: 9.157)

25. Chen, W.-B.; Li, S.-Q.; Chen, L.-J.; Fang, M.-J.; Chen, Q.-C.; Wu, Z.;Wu, Y.-L.*;Qiu, Y.-K.*²Online Polar Two Phase CountercurrentChromatography× High Performance Liquid Chromatography for Preparative Isolation of Polar Polyphenols from Tea Extract in a Single Step.²Journal of Chromatography B, 2015, 997: 179-186. (SCI impact factor: 2.603)

26. Loh, X. J.; Wu, Y.-L.²Cationic Star Copolymers Based on β-Cyclodextrins for Efficient Gene Delivery to Mouse Embryonic Stem Cell Colonies.²Chemical Communications, 2015, 51(54): 10815-10818. [Featured in Back Cover] (SCI impact factor: 6.319)

27. Wang, D.;Chen, L.-J.;Liu, J.-L.;Wang, X.-Y.; Wu, Y.-L.; Fang, M.-J.; Wu, Z.; Qiu, Y.-K.*²On-line Two-dimensional CountercurrentChromatography × HighPerformance Liquid Chromatography System with a Novel FragmentaryDilution and Turbulent Mixing Interface for Preparation of Coumarinsfrom Cnidiummonnieri.²Journal of Chromatography A, 2015, 1406: 215-223. (SCI impact factor: 3.981)

28. Hu, B.; Shi, W.; Wu, Y.-L.; Leow, W. R.; Cai, P.; Li, S.; Chen, X. ²Orthogonally Engineering Matrix Topography and Rigidity to Regulate Multicellular Morphology.² Advanced Materials, 2014, 26(33):5786-5793. (SCI impact factor: 19.791)

29. Yin, S.; Wu, Y.-L.; Hu, B.; Wang, Y.; Cai, P.; Tan, C. K.; Qi, D.; Zheng, L.; Leow, W. R.; Tan, N. S.; Wang, S.; Chen, X. ²Three-dimensional Graphene Composite Macroscopic Structures for Capture of Cancer Cells.²Advanced Materials Interfaces,2014, 1(1):1300043. (SCI impact factor: 4.279)

30. Liu, J.-L.; Wang, X.-Y.; Zhang, L.-L.; Fang, M.-J.; Wu, Y.-L.; Wu, Z.; Qiu, Y.-K. ²Two-dimensional CountercurrentChromatography × High Performance Liquid Chromatography with Heart-cutting and Stop-and-go Techniques for Preparative Isolation of Coumarin Derivatives from Peucedanumpraeruptorum Dunn.²Journal of Chromatography A, 2014, 1374 : 156–163. (SCI impact factor: 3.981)

31. Wu, Y.-L.; Putcha, N.; Ng, K.W.; Leong, D.; Lim, C.T.; Loo, S.C.; Chen, X. ²Biophysical Responses upon the Interaction of Nanomaterials with Cellular Interfaces.²Accounts of Chemical Research,2013, 46(3):782-791. (SCI impact factor: 20.268)

32. Wu, Y.-L.; Yin, H.; Zhao, F.; Li, J. ²Multifunctional Hybrid Nanocarriers Consisting of Supramolecular Polymers and Quantum Dots for Simultaneous Dual Therapeutics Delivery and Cellular Imaging.²Advanced Healthcare Materials,2013, 2(2): 297-301. (SCI impact factor: 5.110)

33. Lam, C.R.; Tan, C.; Teo, Z.; Tay, C.Y.; Phua, T.; Wu, Y.-L.; Cai, P.Q.; Tan, L.P.; Chen, X.; Zhu, P.; Tan, N.S. ²Loss of TAK1 Increases Cell Traction Force in a ROS-dependent Manner to Drive Epithelial-Mesenchymal Transition of Cancer Cells. ²Cell Death & Disease, 2013, 4: e848. (SCI impact factor: 5.965)

34. Cai, L.L.; Ye, H.M.;Lv, X.N.;Wu, Y.-L.; Zhang, H.J.; Zheng, L.M.; Tzeng, C.M. ²25-(OH)VitD3, as a Risk Indicator in Diagnosis of Adenocarcinoma.²Current Drug Targets, 2013, 14(11): 1367-1376. (SCI impact factor: 3.236)

35. Wu, D.-C.; Loh, X.J.; Wu, Y.-L.; Lay, C.L.; Liu, Y. ²’Living’ Controlled in situ Gelling Systems: Thiol-Disulfide Exchange Method toward Tailor-Made Biodegradable Hydrogels.²Journal of the American Chemical Society, 2010, 132(43): 15140-1514. (SCI impact factor: 13.858)

36. Loh, X.J.; Zhang, Z.-X.; Mya, K.Y.; Wu, Y.-L.; He, C.B.; Li, J. ²Efficient Gene Delivery with Paclitaxel-Loaded DNA-Hybrid Polyplexes Based on Cationic Polyhedral Oligomeric Silsesquioxanes.²Journal of Materials Chemistry, 2010, 20(47): 10634-10642. (SCI impact factor: 6.101)

37. Wu, Y.-L.; Li, J. ²Synthesis of Supramolecular Nanocapsules Based on Threading Multiple Cyclodextrins over Polymer on Gold Nanoparticles.²AngewandteChemie International Edition, 2009, 48(21): 3842-3845. [Highlighted by Nature Asia-Pacific: http://www.nature.com/am/journal/2009/200908/full/am2009185a.html] (SCI impact factor: 11.994)

38. Loh, X.J.; Zhang, Z.-X.; Wu, Y.-L.; Lee, T.S.; Li, J. ²Synthesis of Novel Biodegradable Thermoresponsive Triblock Copolymers Based on Poly[(R)-3-hydroxybutyrate] and Poly(N-isopropylacrylamide) and Their Formation of Thermoresponsive Micelles.²Macromolecules, 2009, 42(1): 194-202. (SCI impact factor: 5.835)

39. Loh,X.J.; Wu, Y.-L.; Seow, W.T.J.; Norimzan, M.N.I.; Zhang, Z.-X.; Xu, F.-J.; Kang, E.-T.; Neoh, K.-G.; Li, J. ²Micellization and Phase Transition Behavior of Thermosensitive Poly(N-isopropylacrylamide)–Poly(e-caprolactone)–Poly(N-isopropylacrylamide) Triblock Copolymers.²Polymer, 2008, 49(23): 5084-5094. (SCI impact factor: 3.684)

40. Cui, H.; Zhang, Z.-F.; Shi, M.-J.; Xu, Y.; Wu, Y.-L.²Light Emission of Gold Nanoparticles Induced by the Reaction of Bis(2,4,6-trichlorophenyl) Oxalate and Hydrogen Peroxide.²Analytical Chemistry, 2005, 77(19): 6402-6406. (SCI impact factor: 6.320)

Book Chapters

1. Luo, R.-C.; Wu, Y.-L.; EI-Newehy, M.²The Industrial Productionof PHA.² A Chapter in ²Polyhydroxyalkanoates (PHAs): Biosynthesis, Industrial Production and Applications in Medicine.² (Edited by L.-P.Wu) NOVA Science Publishers, ISBN: 978-1-63321-659-4, 2014, 133-140.

2. Luo, R.-C.; Wu, Y.-L.; EI-Newehy, M.²Extraction and Purification of Polyhydroxyalkanoates.² A Chapter in ²Polyhydroxyalkanoates (PHAs): Biosynthesis, Industrial Production and Applications in Medicine.² (Edited by L.-P.Wu) NOVA Science Publishers, ISBN: 978-1-63321-659-4, 2014, 141-152.

  

联系方式:

地址:厦门市翔安区厦门大学药学院448

电话:0592-2181852

Email wuyl@xmu.edu.cn



 
 
Copyright©2011 http://pharm.xmu.edu.cn 版权所有:厦门大学药学院
地 址:厦门市翔安区翔安南路 邮编:361102 电 话:0592-2182453 2181852
D200695
[后台管理]