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方美娟副教授

发布者:张欧扬发布时间:2016-03-14浏览次数:1465

方美娟博士,副教授  


教育背景:

1997.9—2001.7 厦门大学化学化工学院化学系,理学学士

2001.9—2006.7 厦门大学化学化工学院,有机化学专业,理学博士


工作经历:

2006-2011起,厦门大学药学院,药学系,讲师,硕导。

2014.06-2015.06美国加州大学旧金山分校, Research Associate

2011起,厦门大学药学院,副教授,硕导。


研究简介:

主要从事:小分子代谢;靶向性抗肿瘤或抗HIV活性化合物小分子的设计、合成及活性研究,药物小分子和蛋白大分子间相互作用的研究。现已在Analytica Chimica Acta. Rapid Commun. Mass Spectrom. Organic LettersTetrahedron LettJournal of Asian Natural Products Research等国外重要刊物上发表三十多篇研究型SCI论文和申请国内专利4项。主持国家自然科学基金(青年项目)1项,省部级课题1项,横向课题5项,参与多项国家、省部级课题。


5年发表的研究性论文:

1.Liu, L. N.; Fu, T. T.; Xu, X. F.; Fu, C.; Fang, M. J.*; Liu, Y.; Xu, P. X. and Zhao, Y. F.*. Tracing the nitrogen metabolites of glycine using 15N-glycine and mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29, 645-653.

2.Fang, M. J.*; Zhang, H.; Liao, C.; Qiu, Y. K.; Fang, H.; Zheng, Z. Y.; Gao, X.; Zhao, Y. F.;Wu, Z.; Fragmentation  Mechanisms about Phosphorylation-Dephosphorylation Involved in Amino  Acid Ester Isopropyl Phosphoramidates of Brefeldin A Studied by Tandem  Mass Spectrometry and Stable Isotopic Labeling, Analytica Chimica Acta. 853 (2015) 391-401.

3.Chen, J. W.; He, Z.; Wu, Z.; Fang, M. J.* and Fang, H. (2z, 4E)-1-(5-fluoro-2- hydroxyphenyl)-5-(4-fluorophenyl)-3-hydroxypenta-2,4-dien-1-one. Acta Cryst. (2014). E70, o88.

4.Qiu, Y. K.; Yan, X.; Fang, M. J.;  Chen, L.; Wu, Z.; Zhao, Y. F. Two-dimensional countercurrent  chromatography × highperformance liquid chromatography for preparative  isolation of toad venom. Journal of Chromatography A. 1331 (2014) 80-89.

5.Yan, X.; Tang, X. X.; Chen, L.; Yi, Z. W.; Fang, M. J.; Wu, Z. and Qiu, Y. K.. Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone. Mar. Drugs, 12 (2014) 2156-2163.

6.Qiu, Y. K.; Chen, F. F.; Zhang, L. L. Yan, X.; Chen, L.; Fang, M. J.;  and Wu, Z.. Two-dimensional preparative liquid chromatography system  for preparative separation of minor amount components from complicated  natural products. Analytica Chimica Acta. 820 (2014) 176-186.

7.Fang M. J. *, Fang H., Li W. J., Huang D. M, Wu Z., Zhao Y. F. A new diphenyl ether from Phoma sp strain, SHZK-2. Natural Product Research, 2012, 26(13): 1224-1228.

8.Zhuang R. Q., Xu J. A., Cai Z. S., Tang G., Fang M. J. *, Zhao Y. F*. Copper-Catalyzed C_P Bond Construction via Direct Coupling of Phenylboronic Acids with H-Phosphonate Diesters. Organic Letters, 2011, 13(8): 2110-2113.

9.Fang, H.; Xie, X. L.; Hong, B. H.; Zhao, Y. F.; Fang, M. J*, Copper (I) Iodide-Catalyzed Solvent-Free Synthesis of alpha-Aminophosphonates. Phosphorus sulfur and Sillcon and the Related Elements, 2011, 186 (11): 2145-2155.

10.Fang H., Chen W. Z., Hong B. H., Zhao Y. F., Fang M. J*. Synthesis, characterizations, and crystal structures of hydroxyphosphonic acid esters. Phosphorus sulfur and Sillcon and the Related Elements, 2010, 185 (11): 2182-2193.

11.Zheng Z. Y., Liu Y., Cai Z. S., Zhang, H. W., Fang H., Fang M. J. *, Zhao Y. F. Electrospray ionization tandem mass spectrometry of phosphonate peptides. European Journal of Mass Spectrometry, 2010, 16(4): 503-509.

12.Gao, X.; Zhuang, R. Q.; Guo, J. N.; Bao, J.; Fang, M. J.; Liu, Y.; Xu, P. X.; Zhao, Y. F..  Isolation and purification of macrocyclic components from Penicillium  fermentation broth by high-speed counter-current chromatography. Journal of Separation Science, 2010, 33(2): 277-284.


联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院

邮编:361102

Email: fangmj@xmu.edu.cn


 
 
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