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曾锦章教授

发布者:张欧扬发布时间:2016-03-14浏览次数:3371


PI:曾锦章博士、教授、博士生导师

药学院副院长 福建省药物新靶点研究重点实验室副主任,福建省双百计划科技创新领军人才


  

个人简介:  

1989年毕业于第一军医大学医疗系本科,并于19951998年分别获医学硕士和博士学位;1998-2005第二军医大学东方肝胆外科医院国际合作生物信号转导研究中心工作;2006-2007在美国Burnham医学研究所工作;2007到厦门大学生物医学研究院组建癌症研究中心。获上海市医学科技奖一等奖和上海市科技进步奖二等奖各1项,担任Cancer Res, Carcinogenesis, Molecular Cancer, Biochem PharmacolBMC CancerCurr Top Med Chem, Genomics Proteomics and BioinformaticsActaPharmacol Sin等杂志资深审稿人 (Peer Reviewer)。是Cancer Res, Carcinogenesis, Molecular Cancer,BiochemPharmacolBMC CancerCurr Top MedChem, Genomics Proteomics and BioinformaticsActaPharmacol Sin等杂志资深审稿人 (Peer Reviewer)。近年,主持了包括国家高技术研究发展计划(国家863项目, 2007AA09Z404)、科技部国家国际科技合作专项(第十期中国新加坡联合研究计划JRP10S2014GR0448)、国家自然科学基金(30971445300708333007034531340029)、国家自然科学基金与香港研究资助局联合科研基金(30931160431N_HKU 735/09)、国家自然科学基金重大研究计划(90913015,合作申请)、福建省重点项目(2007I00232012I0010)、福建省自然科学基金项目(2009J01198)以及海洋重大专项等十余项科研项目。

主要研究领域

主要从事肿瘤信号转导和抗癌药物的研究工作,稍早期主要开展肝癌相关基因的克隆、鉴定、功能研究,以发现肝癌新的分子标志物,近年来主要研究核受体在调控细胞生长、凋亡、代谢和免疫中的作用,研究其信号转导调控机制,以鉴定新的治疗靶点,并籍此新的信号转导的理解,对可能的治疗药物进行改进与优化。

核受体(nuclear receptors)是类固醇激素、甲状腺激素、性激素、维甲酸、维生素D等化学信号的受体及配体未明的多种孤儿核受体,是人体细胞核最大的超家族蛋白,对生长发育、新陈代谢、细胞分化及各种病理生理过程均有极其重要的调节作用。这类受体通常在核内作为转录因子调控靶基因的表达,有趣的是,几乎所有的核受体还存在一种不依赖于其转录调控的新型分子机制起作用,称为核受体的非基因型功能,这种新型作用机制的发现是近10年来核受体研究领域最重大的进展之一,为开发新型治疗药靶提供了新的依据。这种非基因型作用主要是在疾病过程中由于应激、癌基因活化及代谢产物的刺激等,使核受体发生磷酸化修饰、甚至切割,并转位到细胞质和线粒体,是细胞核蛋白参与线粒体功能调控的典型代表。这些受体转位到线粒体后,可以启动线粒体的死亡通 路、影响线粒体的能量和物质代谢。

团队成员:刘杰,助理教授。先后在Developmental Cell, FEBS Journal, JBC等杂志上发表文章。承担国家自然科学基金,福建省自然科学基金,福建省卫生厅等多个科研项目。实验室每年招收博士生1-2名,硕士生3-4名。

在研项目:国家自然科学基金面上项目2国家自然科学基金国际合作项目1项,国际合作科技专项1项,厦门市南方海洋中心项目1项,福建省卫生厅项目1项,双百人才计划1项。

近年发表的主要文章(*通讯作者)

  1.  Zeng W, Zhang C, Cheng H, Wu YL, Liu J, Chen Z, Huang JG, Ericksen RE, Chen L, Zhang H, Wong AS, Zhang XK, Han W, Zeng JZ*.Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Sci Rep. 2017 Mar 23;7(1):348. doi: 10.1038/s41598-017-00233-5.(SCI impact factor: 5.228)

  2.  Wang PY, Zeng WJ, Liu J, Wu YL, Ma Y, Zeng Z, Pang JY, Zhang XK, Yan X, Wong AS, Zeng JZ*.TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells. Biochem Pharmacol. 2017 Jan 15;124:19-28. doi: 10.1016/j.bcp.2016.10.014. Epub 2016 Oct 31.(SCI impact factor: 5.091)

  3.  Liu J, Wang H, Cheng G, Yang M, Wu ZX, Ericksen RE, Wong AS, Han W,* and Zeng JZ*. Journal of Cancer Metastasis and Treatment, 2017 August, DOI:10.20517/2394-4722.2017.46

  4.  Chen C, Zhang X, Zhang S, Zhu S, Xu J, Zheng Y, Han J, Zeng JZ, Yan X.Quantification of protein copy number in single mitochondria: The Bcl-2 family proteins. Biosens Bioelectron. 2015 Dec 15;74:476-82. doi: 10.1016/j.bios.2015.06.057. Epub 2015 Jul 3. (SCI impact factor: 7.476)

  5.  To SKY, Zeng WJ, Zeng JZ*, Wong AT. Hypoxia triggers a Nur77--catenin feed-forward loop to promote the invasive growth of colon cancer cells. Br J Cancer 2014, 110, 935–945 (SCI impact factor: 5.082)

  6.  Zhang X, Zhang S, Zhu S, Chen S, Han J, Gao K, Zeng JZ, Yan X. Rapid Identification of Mitochondria-Targeting Anticancer Drugs by an in vitro Strategy. Anal Chem. 2014 Jun 3;86(11):5232-7. doi: 10.1021/ac500918g. Epub 2014 May 21.(SCI impact factor: 5.886)

  7.  Wang  GH, Jiang FQ, Duan YH, Zeng ZP, Chen F, Dai Y,Chen J, Liu JX, Liu  J,Zhou H, Chen HF, Zeng JZ, Su Y, Yao XS*, Zhang XK*. Targeting truncated retinoid X receptor-αby CF31 induces TNF-α-dependent apoptosis. Cancer Research2013, 73(1), 307-318 (SCI impact factor:  8.65).

  8.  Gao  W, Liu J, Hu M,Huang M, Cai S,Zeng ZP, Lin B, Cao X, Chen J, Zeng JZ,  Zhou H*, Zhang XK*. Regulation of proteolyticcleavage of retinoid X receptor-alpha by GSK-3β. Carcinogenesis.  doi: 10.1093/carcin/bgt043First published online: February 6, 2013 (SCI  impact factor: 5.702).

  9.  Ren  J, Liu D, Tian L, Wei Y, Proksch P, Zeng JZ*, Lin W*. Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77. Bioorg Med Chem Lett 2013, 23(1): 301-304 (SCI impact factor: 2.554)

  10.  Zhang  S, Zhu S, Yang L, ZhengY, Gao M, Wang S, Zeng JZ, Yan X*.  High-Throughput Multiparameter Analysis of Individual Mitochondria. Anal  Chem 2012, 84 (15), 6421–6428DOI: 10.1021/ac301464x

  11.  Wang  G, Guo X, Chen H, Lin T, Xu Y, Chen Q, Liu J, Zeng JZ, Zhang XK, Yao  X*. A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Bioorg Med Chem Lett 2012,22:2014-8 (doi:10.1016/j.bmcl.2011.12.095)(SCI impact factor: 2.554)

  12.  To SK, Zeng JZ, Wong AS*. Nur77: a potential therapeutic target in  cancer.Expert OpinTher Targets2012,16(6): 573-585  (doi:10.1517/14728222.2012.680958)(SCI impact factor:4.13)

  13.  Lu N, Liu JX, Liu J, Zhang C, Jiang F, Wu H, Chen L, Zeng WJ, Cao  X, Yan T, Wang G, Zhou H, Lin B, Yan X, ZhangXK*, Zeng JZ*.Antagonist  Effect of Triptolideon AKT Activation by Truncated Retinoid X  Receptor-alpha. PLoS ONEApril 2012 | Volume 7 | Issue 4 | e35722 (doi:  10.1371/journal.pone.0035722)(SCI impact factor:4.41)

  14.  Wei  GQ, Zheng YN, Li W, Liu WC, Lin T, Zhang WY, Chen HF, Zeng JZ, Zhang  XK, Chen QC*. Structural modification of ginsenoside Rh2 by fatty acid esterification and its detoxification property in antitumor. Bioorg Med Chem Lett2012, 22, 1082-1085(SCI impact factor: 2.554).

  15.  Sun  Z, Cao X, Jiang MM, Qiu Y, Zhou H, Chen L, Qin B, Wu H, Jiang F, Chen  J, Liu J, Dai Y, Chen HF, Hu QY, Wu Z, Zeng JZ, Yao XS*, Zhang XK*. Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77.  Oncogene 2012, 31(21):2653-67(doi: 10.1038/onc.2011.448.)(SCI impact factor:7.357)

  16.  Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK*, Zeng JZ*.Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.FASEB J2011; 25:192-205. (SCI impact factor:6.515)

  17.  Zhou H, Wen L, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan TD, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, and Zhang XK*. Sulindac and its analogs bind RXRa and inhibits RXRa-dependent AKT signaling. Cancer Cell 2010;15: 560–573(SCI impact factor: 24.755).

  18.  Yan  TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, He  JY, Gao WW, Zhao Y, Xie L, Zhang XK*, and Zeng JZ*. Oncogenic Potential of Retinoic Acid Receptor-gamma in Hepatocellular Carcinoma.Cancer Res 2010,70(6):2285-2295(SCI impact factor: 8.65).

  19.  Zhou L, Shen LH, Hu LH, Ge H, Pu J, Chai DJ, Shao Q, Wang L, Zeng JZ, He B*.Retinoid  X receptor agonists inhibit phorbol-12-myristate-13-acetate  (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.Mol Cell Biochem2010;335(1-2):283-289(SCI impact factor: 2.329).

  20.  Han  YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, ZengJZ,  Zhang XK*. A unique cytoplasmic localization of RARgamma and its regulations. J BiolChem, 2009;284(27):18503-18514(SCI impact factor:  4.65).

  21.  Liu  J, Zhou W, Li SS, Sun Z, Lin B, Lang YY, He JY, Cao X, Yan T, Wang L,  Lu J, Han YH, Cao Y, Zhang XK*, and Zeng JZ*. Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogs. Cancer Res, 2008, 68(21):8871–8880(SCI impact factor: 8.65). 该文章被《自然中国(Nature China)选为来自中国大陆和香港的突出科学研究成果,并邀请专家进行亮点评论介绍给广大读者。

  22.  Shen LH,Zhou L, Wang BY, Bu J, Hu LH, Chai DJ, Wang L,ZengJZ, He B*.Oxidized low-density lipoprotein induces differentiation of RAW264.7 murine macrophage cell line into dendritic like cells.Atherosclerosis 2008, 199(2):257-264(SCI impact factor: 3.705).

  23.  Jiang  MM, Dai Y, Gao H, Zhang X, Wang GH, He JY, Hu QY, Zeng JZ, Zhang XK,  Yao XS*. Cardenolides from Antiaristoxicaria as potent selective Nur77 modulators.Chem Pharm Bull2008, 56(7) 1005-1008(SCI impact factor:  1.564).

  24.  Zeng JZ, Zhang XK*.Nongenomic actions of retinoids: role of Nur77 and RXR in the regulation of apoptosis and inflammation.Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2007, 6 (4): 315-331.

  25.  Zeng  JZ*, Sun DF, Wang L, Qi JB, Yang T, Hu CQ, Liu W, Zhang XK.  Hypericumsampsonii induces apoptosis and nuclear export of retinoid X receptor-alpha. Carcinogenesis, 2006, 27 (10):1991-2000 (SCI impact factor: 5.702).

  26.  Zeng JZ, Wang HY*, Chen ZJ, Ullrich A, Wu MC. Molecular cloning and characterization of a novel gene which is highly expressed in  hepatocellular carcinoma.Oncogene, 2002, 21:4932-4943 (SCI impact  factor: 7.357).


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Email: jzzeng@xmu.edu.cn







 
 
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