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Dieter A. Wolf教授

发布者:张欧扬发布时间:2016-03-14浏览次数:3121

PI:Dr.Dieter A. Wolf



Dieter A. Wolf教授于2014年入选中组部外专千人计划,他曾担任哈佛大学公共卫生学院环境与健康蛋白质组学研究中心主任,以及Sanford-Burnham研究所蛋白质组学研究中心主任等职务,2015年起任职于厦门大学药学院。

Dieter A. Wolf教授在德国慕尼黑大学获得医学博士学位,先后在德国环境与健康研究所、美国哈佛大学医学院、斯坦福大学医学院从事博士后研究,1998年起任职于哈佛大学公共卫生学院。Dieter A. Wolf教授主要研究蛋白质动态平衡机制及其在肿瘤发生过程中的作用,他在抗癌药物的靶标筛选等方面有着卓越的研究成果。针对相关信号转导路径,特别是蛋白质合成和泛素-蛋白酶系统调控的蛋白质降解通路,研究团队利用蛋白质组学和代谢组学手段,发现了与前列腺癌和衰老疾病相关蛋白的质量控制及应激反应通路,率先全面系统地分析了真核细胞的蛋白质组,并对真核细胞中的mRNA和蛋白表达差异进行了大规模比对分析。Dieter A. Wolf教授先后在国际一流学术期刊包括Science, Cell, PNAS, Nature Cell Biology, Nature Communications以及Cancer Cell等等发表了具有国际影响力的研究论文,担任多家国际一流杂志编委和科学顾问。

Dr. Wolf studied medicine at the  University in Munich, Germany. After postdoctoral work at Harvard  Medical School and Stanford University School of Medicine, he joined the  Department of Cancer Cell Biology at Harvard as an Assistant Professor  in 1998. In 2007, Dr. Wolf moved to  Sanford-Burnham Medical Research Institute as Professor and Director of  Proteomics. In 2015, Dr. Wolf was recruited to Xiamen University’s  School of Pharmaceutical Sciences as a Foreign 1000 Talents Professor.


Dr. Wolf’s research focuses on protein  quality control and associated stress response pathways and their  utility as cancer drug targets. Among the most significant achievements  were the identification of BTB proteins as substrate adapters of  cullin3-based ubiquitin ligases and studies on the regulation of  cullin-RING ubiquitin ligases by deneddylation. The lab has also  addressed the proteolytic control of the prostate tumor suppressor p27. A  major achievement was the identification of compound SMIP004 as an  inhibitor of 27 degradation and an inducer of cancer cell-selective  apoptosis in prostate cancer cells through Unfolded Protein Response  signaling downstream of mitochondrial inhibition.

Proteomic technology employing LC-MS/MS  for comprehensive protein profiling and analysis of the dynamics of  protein complexes has been central to this work. Among the most recent  achievements using proteomicswere the identification of the  “translasome“ as a direct physical link between the protein synthesis  and degradation machineries, the demonstration that CAND1 is a factor  controlling the dynamic assembly of cullin-RING ubiquitin ligases, a  systems view of gene expression in response to oxidative stress, and  quantitative profiling of drug effector pathways in prostate cancer  cells. This research also employs network-based and mathematical  modeling approaches.


At Xiamen University, Dr. Wolf’s lab  will focus on castration-resistant prostate cancer - a major health  issue in China and beyond - establishing patient-derived xenograft  models, in vivo loss-of-function screens, and cancer proteomics for the  identification of novel drug targets. A second focus concerns mechanisms  controlling protein synthesis, their roles in cancer, and their  potential as novel drug targets.


Wolf,  D.A. (2014) Is reliance on mitochondrial respiration a chink in the  armor of therapy-resistant cancer? Cancer Cell 26, 788-795


Yang C.-C.; Chung, A.; Brill, L.M.;  Williams, R.; Wolf, D.A. (2014) Systems analysis of the prostate tumor  suppressor NKX3.1 supports roles in DNA repair and luminal cell  differentiation. F1000Research 2014, 3:115


Rico-Bautista, E.; Zhu, W.; Kitada, S.; Ganapathy, S.; Lau, E.; Krajewski, S.; Ramirez, J.; Bush, J.A.; Yuan, Z.; Wolf, D.A.(2013)  Small molecule-induced mitochondrial disruption directs prostate cancer  inhibition via unfolded protein response signaling. Oncotarget 4,  1212-1229 -


Wu, S..; Zhou, W.; Nhan, T.; Toth J.I.;  Petroski, M.D.; Wolf, D.A. (2013) CAND1 controls in vivo dynamics of the  cullin 1-RING ubiquitin ligase repertoire. Nature Communications 4,  1642


Bauer, F.; Matsuyama, A.; Candiracci,  J.; Dieu, M.; Scheliga, S.; Wolf, D.A.; Yoshida, M.; Hermand, D. (2012)  Translational control of cell division by elongator. Cell Reports 1,  424-433 - This article was cited here


Lackner, D.H.; Schmidt, M.W.; Wu, S.;  Wolf, D.A., Bähler, J. (2012) Regulation of transcriptome, translation,  and proteome in response to environmental stress in fission yeast.  Genome Biology 13:R25


Keren-Kaplan, T.; Attali, I.,  Motamedchaboki, K.; Davis, B.A.; Tanner, N., Reshef, Y., Laudon, E.;  Kolot, M.; Levin-Kravets, O.; Kleifeld, O.; Glickman, M.; Horazdovsky,  B.F.; Wolf, D.A., Prag, G. (2012) Synthetic biology approach to  reconstituting the ubiquitylation cascade in bacteria. EMBO J., 31, 378 -  390


Rico-Bautista, E.; Yang, C.-C.; Lu, L.;  Roth, G.P.; Wolf, D.A. (2010) Chemical genetics approach to restoring  p27Kip1 reveals novel compounds with antiproliferative activity in  prostate cancer cells. BMC Biology 8:153

联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院365

邮编:361102

电话:0592-2881135

传真:0592-2181879

实验室网页:http://dieter-wolf-lab-xmu.strikingly.com/

Email:dwolf@xmu.edu.cn


 
 
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