PI：任长亮博士、教授、博士生导师
国家级青年人才项目入选者
“闽江学者”特聘教授
厦门大学“南强青年拔尖A类人才”
个人简介：
任长亮博士，主要致力于仿生人工离子通道的开发，及其作为潜在小分子药物在抗肿瘤和治疗因通道缺陷引发的相关疾病的应用。目前，已开发出多种具有高选择性、高跨膜传输活性和门控特性的人工离子通道，并用其在抗肿瘤和抗肝纤维化方面取得了显著的成效。目前，已在Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等多个国际权威期刊上发表论文30余篇。获4项国际专利、2项美国专利和1项中国专利授权，其中1项已实现技术转化。博士期间，获2011年度“国家优秀自费留学生奖学金”。2016年指导学生参加“新加坡科学与工程竞赛”获得金牌。2022年指导学生参加“福建省互联网+大学生创新创业大赛获得金奖，并获评优秀创新创业指导教师。课题组主要研究方向：（1）人工离子通道的合成及其在抗菌、抗肿瘤和抗肝纤维化方面的应用；（2）人工纳米孔的合成及其在DNA跨膜传输中的应用。
工作经历：
2020 –至今 厦门大学药学院，教授
2019 - 2020 新加坡科技研究局纳米生物实验室，研究科学家（合作导师：Zeng Huaqiang 教授）
2014 - 2019 新加坡科技研究局生物工程与纳米技术研究院，研究科学家（合作导师：Zeng Huaqiang 教授）
2012 - 2014 新加坡科技研究局材料研究与工程研究院，科学家I（合作导师：Li Xu 高级科学家）
2011 - 2012 新加坡国立大学，研究助理（合作导师：Chang Young-Tae 教授）
教育背景：
2007 - 2012 新加坡国立大学，博士，专业：药物化学（导师：Zeng Huaqiang 教授）
2003 - 2007 四川大学，学士，专业：化学（导师：王玉忠 教授）
代表性论文：
1、Z. Chen, X. Xie, C. Jia, Q. Zhong, Q. Zhang, D. Luo, Y. Cao, Y. Mu and C. Ren*, “Concentration-Driven Evolution of Adaptive Artificial Ion Channels or Nanopores with Specific Anticancer Activities” Angew. Chem. Int. Ed. 2024, e202318811.
2、Q. Zhong, Y. Cao, X. Xie, Y. Wu, Z. Chen, Q. Zhang, C. Jia, Z. Wu, P. Xin, X. Yan, Z. Zeng and C. Ren*, “Non-Covalently Stapled H+/Cl- Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy” Angew. Chem. Int. Ed. 2023, 62, e202314666 (VIP)
3、J. Shen, Y. Gu, L. Ke, Q. Zhang, Y. Cao, Y. Lin, Z. Wu, C. Wu, Y. Mu, Y.-L. Wu, C. Ren*and H. Zeng*, “Cholesterol-Stabilized Membrane-Active Nanopores with Anticancer Activities” Nat. Commun. 2022, 13, 5985
4、Z. Dong, W. Feng, C. Huang, H. Lin, C. Jia and C. Ren*, “Superhydrophobic Melamine Sponges with High Performance in Oil/Organic Solvent Sorption” J. Environ. Chem. Eng. 2023, 11, 110614
5、P. Ma, Z. Luo, Z. Li, Y. Lin, Z. Li*, Z. Wu, C. Ren*, Y.-L. Wu*, “Mitochondrial Artificial K+ Channel Construction Using MPTPP@5F8 Nanoparticles for Overcoming Cancer Drug Resistance via Disrupting Cellular Ion Homeostasis” Adv. Healthc. Mater. 2023, 12, 2302012 .
6、 C. Ren*, P. Talukdar* and H. Zeng* “Artificial Membrane Transporters” Front. Chem. 2022, 10, 841159 .
7、C. Ren, F. Chen, R. Ye, Y. S. Ong, H. Lu, S. S. Lee, J. Y. Ying and H. Zeng*, “Molecular Swings as Highly Active Ion Transporters,” Angew. Chem. Int. Ed. 2019, 58, 8034-8038 (Hot Paper, News Reports in Asia Today, Asia Pacific Biotech News)
8、R. Ye#, C. Ren#, J. Shen, N. Li, F. Chen, A. Roy and H. Zeng*, “Molecular Ion Fishers as Highly Active and Exceptionally Selective K+ Transporters,” J. Am. Chem. Soc. 2019, 141, 9788-9792 . (# equal contribution)
9、C.Ren, F. Zeng, J. Shen, F. Chen, A. Roy, S Zhou, H. Ren and H. Zeng*, “Pore-forming Monopeptides as Exceptionally Active Anion Channels,” J. Am. Chem. Soc. 2018, 140, 8817-8826 . (Featured in Asian Scientist)
10、C. Ren, J. Shen and H. Zeng*, “Combinatorial Evolution of Fast-Conducting Highly Selective K+-Channels via Modularly Tunable Directional Asembly of Crown Ethers,” J. Am. Chem. Soc. 2017, 139, 12338-12341 . (Featured in Phys.org)
11、C. Ren, J. Shen, F. Chen and H. Zeng*, “Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator,” Angew. Chem. Int. Ed. 2017, 56, 3847-3851
12、C. Ren, V. Maurizot, H. Zhao, J. Shen, F. Zhou, W. Q. Ong, Z. Du, K. Zhang, H. Suand H. Zeng*, “Fivefold-Symmetric Aromatic Pentamers: High Affinity Cation Recognition, Ion-Pair Induced Columnar Stacking and Nanofibrillation,” J. Am. Chem. Soc. 2011, 133, 13930-13933.
13、C. Ren, F. Zhou, B. Qin, R. J. Ye, S. Shen,H. B. Su and H. Zeng*, “Crystallographic Realization of the Mathematically Predicted Densest ‘All Pentamer’ Packing Lattice by C5-symmetric ‘sticky’ fluoropentamers,” Angew. Chem. Int. Ed. 2011, 50, 10612-10615.
14、C. Ren, X. Ding, A. Roy, J. Shen, S Zhou, F. Chen, S. F. Y. Li, H. Ren, Y. Y. Yang and H. Zeng*, “A Halogen-bond Mediated Highly Active Artificial Chloride Channel with High Anti-cancer Activity,” Chem. Sci. 2018, 9, 4044-4051 . (Outside Cover, Featured in Chemistry Views)
15、C. Ren, G. H. B. Ng, H. Wu, K.-H. Chan, J. Shen, C. Teh, J. Y. Ying and H. Zeng*, Instant Room-Temperature Gelation of Crude Oils by Chiral Organogelators, Chem. Mater. 2016, 28, 4001-4008. (News Reports in Channel News Asia, Strait Times, Asian Scientist, Maritime Journal, Asia Oil & Gas Magazine, A*STAR TV)
16、C. Ren, F. Chen, F Zhou, J Shen, H Su and H. Zeng*, “Low-Cost Phase-Selective Organogelators for Rapid Gelation of Crude Oils at Room Temperature, Langmuir 2016, 32, 13530-13536 .
17、C .Ren, J. Shen, and H. Zeng*, One-Pot Synthesis of Strained Macrocyclic Pyridone Hexamers and Their High Selectivity toward Cu2+ Recognition, Org. Lett. 2015, 24, 5946-5949 .
18、C. Ren, G. H. B. Ng, X. Li and C. Teh*, “SNC-Coumarin is a Biocompatible Imaging Agent for In Vivo Labeling of Cells and Fluids,“ Nano LIFE 2015, 5, 1540004 .
19、W. Xu#, C. Ren#, C. L. Teoh#, J. Peng, H. W. Rhee, C. L. K. Lee and Y. T. Chang*, “An Artificial Fluorescent Sensor Array for Indentification and Quantitation of Various Heavy Metal Ions,” Anal. Chem. 2014, 84, 8763-8769 . (# equal contribution)
20、C. Ren, S. Xu, J. Xu, H. Y. Chen and H. Zeng*, “Planar Macrocyclic Fluoropentamers as Supramolecular Organogelators,” Org. Lett. 2011, 13, 3840-3843 .
招聘:本课题组诚招助理教授，博士后，博士及硕士研究生（长期有效）。如有意向，欢迎附简历来信垂询。
联系方式:
电子邮箱：changliang.ren@xmu.edu.cn
地址：福建省厦门市翔安区翔安南路厦门大学翔安校区药学院223室
邮编：361102
